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      Minerals and Bone-Modulating Hormones in Children on Continuous Ambulatory Peritoneal Dialysis

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          Abstract

          Peritoneal fluxes of minerals and bone-modulating hormones and their impact on corresponding serum levels and bone mineralization in 7 children on continuous ambulatory peritoneal dialysis (CAPD) were studied. Most mass transfer studies revealed modest losses of calcium into peritoneal effluents. Peritoneal losses of phosphorus and magnesium, although substantial, were not sufficient to normalize hyperphosphatemia and hypermagnesemia in most patients. Parathormone and vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin D) were readily detectable in peritoneal effluents. Improved bone mineral content, by sequential densitometries, was associated with amelioration of hyperparathyroidism. These data suggest that CAPD in children induces an overall improvement of disturbed mineral metabolism; nevertheless, peritoneal losses of calcium and vitamin D metabolites must be considered and replenished appropriately.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 41
          : 3
          : 267-272
          Affiliations
          Departments of aPediatrics and bMedicine, University of Miami School of Medicine, Miami, Fla., USA
          Article
          183595 Nephron 1985;41:267–272
          10.1159/000183595
          3840576
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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