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      Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations.

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          Abstract

          Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy, characterized by t(6;9) translocations and MYB-NFIB gene fusions in approximately 50% of the tumors. The genetic alterations underlying t(6;9)-negative and t(6;9)-positive/MYB-NFIB fusion-negative ACC remain unknown. To uncover the genetic alterations in ACC lacking the canonical translocation and fusion transcript and identify new abnormalities in translocation positive tumors.

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          Author and article information

          Journal
          Clin. Cancer Res.
          Clinical cancer research : an official journal of the American Association for Cancer Research
          American Association for Cancer Research (AACR)
          1078-0432
          1078-0432
          Feb 01 2016
          : 22
          : 3
          Affiliations
          [1 ] Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
          [2 ] Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
          [3 ] Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
          [4 ] Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
          [5 ] Department of Thoracic/Head and Neck Medicine Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
          [6 ] Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
          [7 ] Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. anaggar@mdanderson.org ccaulin@mdanderson.org.
          [8 ] Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. anaggar@mdanderson.org ccaulin@mdanderson.org.
          Article
          1078-0432.CCR-15-2867-T NIHMS743089
          10.1158/1078-0432.CCR-15-2867-T
          4807116
          26631609

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