Yoshitsugu Mitani 1 , Bin Liu 2 , Pulivarthi H Rao 3 , Vishnupriya J Borra 3 , Mark Zafereo 4 , Randal S Weber 4 , Merrill Kies 5 , Guillermina Lozano 2 , P Andrew Futreal 6 , Carlos Caulin 7 , Adel K El-Naggar 8
Feb 01 2016
Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy, characterized by t(6;9) translocations and MYB-NFIB gene fusions in approximately 50% of the tumors. The genetic alterations underlying t(6;9)-negative and t(6;9)-positive/MYB-NFIB fusion-negative ACC remain unknown. To uncover the genetic alterations in ACC lacking the canonical translocation and fusion transcript and identify new abnormalities in translocation positive tumors.