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      Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

      research-article
      1 , , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 9 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 11 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 3 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 5 , 58 , 59 , 60 , 61 , 62
      Intensive Care Medicine
      Springer Berlin Heidelberg
      Sepsis, Septic shock, Adults, Guidelines, Evidence based medicine

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          Most cited references658

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          The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

          Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination.
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            • Article: not found

            GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.

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              • Abstract: not found
              • Article: not found

              Meta-analysis in clinical trials

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                Author and article information

                Contributors
                leevans@uw.edu
                Journal
                Intensive Care Med
                Intensive Care Med
                Intensive Care Medicine
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0342-4642
                1432-1238
                2 October 2021
                : 1-67
                Affiliations
                [1 ]GRID grid.34477.33, ISNI 0000000122986657, Division of Pulmonary, Critical Care and Sleep Medicine, , University of Washington, ; Seattle, WA USA
                [2 ]GRID grid.451349.e, Adult Critical Care, , St George’s University Hospitals NHS Foundation Trust & St George’s University of London, ; London, UK
                [3 ]GRID grid.25073.33, ISNI 0000 0004 1936 8227, Department of Health Research Methods, Evidence, and Impact, , McMaster University, ; Hamilton, ON Canada
                [4 ]GRID grid.411075.6, ISNI 0000 0004 1760 4193, Dipartimento di Scienze dell’Emergenza, Anestesiologiche e della Rianimazione, , Policlinico Universitario A. Gemelli IRCCS, ; Rome, Italy
                [5 ]GRID grid.189967.8, ISNI 0000 0001 0941 6502, Emory University School of Medicine, ; Atlanta, GA USA
                [6 ]GRID grid.417072.7, ISNI 0000 0004 0645 2884, Western Health, ; Melbourne, Australia
                [7 ]GRID grid.413463.7, Anesthesiology, Pain and Intensive Care Department, , Federal University of São Paulo, Hospital of São Paulo, ; São Paulo, Brazil
                [8 ]GRID grid.412687.e, ISNI 0000 0000 9606 5108, Ottawa Hospital, ; Ottawa, ON Canada
                [9 ]GRID grid.420545.2, Guy’s & St Thomas’ Hospital, ; London, England, UK
                [10 ]GRID grid.497654.d, ISNI 0000 0000 8603 8958, University of Michigan and VA Center for Clinical Management Research, ; Ann Arbor, MI USA
                [11 ]GRID grid.421534.5, ISNI 0000 0004 0524 8072, Cooper Health System, ; Camden, NJ USA
                [12 ]GRID grid.412016.0, ISNI 0000 0001 2177 6375, University of Kansas Medical Center, ; Kansas City, KS USA
                [13 ]GRID grid.7177.6, ISNI 0000000084992262, ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis, Division of Infectious Diseases, , Amsterdam UMC, University of Amsterdam, ; Amsterdam, The Netherlands
                [14 ]Department of Internal Medicine, College of Medicine and Health Sciences, Emirates University, Al Ain, United Arab Emirates
                [15 ]GRID grid.21925.3d, ISNI 0000 0004 1936 9000, University of Pittsburgh Critical Care Medicine CRISMA Laboratory, ; Pittsburgh, PA USA
                [16 ]GRID grid.412149.b, ISNI 0000 0004 0608 0662, Intensive Care Department, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, , King Saud Bin Abdulaziz University for Health Sciences, ; Riyadh, Kingdom of Saudi Arabia
                [17 ]GRID grid.11899.38, ISNI 0000 0004 1937 0722, School of Medicine, , University of Sao Paulo, ; São Paulo, Brazil
                [18 ]GRID grid.17635.36, ISNI 0000000419368657, University of Minnesota, ; Minneapolis, MN USA
                [19 ]GRID grid.415102.3, ISNI 0000 0004 0545 1978, Population Health Research Institute, ; Hamilton, ON Canada
                [20 ]GRID grid.17063.33, ISNI 0000 0001 2157 2938, Mount Sinai Hospital & University of Toronto (Leslie Dan Faculty of Pharmacy), ; Toronto, ON Canada
                [21 ]GRID grid.452490.e, Department of Biomedical Sciences, , Humanitas University Pieve Emanuele, ; Milan, Italy
                [22 ]GRID grid.417728.f, ISNI 0000 0004 1756 8807, Department of Anaesthesia and Intensive Care, , IRCCS Humanitas Research Hospital, ; Rozzano, Milan, Italy
                [23 ]GRID grid.25073.33, ISNI 0000 0004 1936 8227, Department of Anesthesia, , McMaster University, ; Hamilton, ON Canada
                [24 ]GRID grid.266539.d, ISNI 0000 0004 1936 8438, Lexington Veterans Affairs Medical Center/University of Kentucky College of Medicine, ; Lexington, KY USA
                [25 ]GRID grid.410566.0, ISNI 0000 0004 0626 3303, Ghent University Hospital, ; Ghent, Belgium
                [26 ]GRID grid.26999.3d, ISNI 0000 0001 2151 536X, The University of Tokyo, ; Tokyo, Japan
                [27 ]GRID grid.413106.1, ISNI 0000 0000 9889 6335, Medical ICU, , Peking Union Medical College Hospital, ; Beijing, China
                [28 ]Hospital Interzonal de Agudos San Martin de La Plata, Buenos Aires, Argentina
                [29 ]GRID grid.411083.f, ISNI 0000 0001 0675 8654, Intensive Care Department, , Vall d’Hebron University Hospital, Vall d’Hebron Institut de Recerca, ; Barcelona, Spain
                [30 ]GRID grid.415197.f, ISNI 0000 0004 1764 7206, Prince of Wales Hospital, ; Hong Kong, China
                [31 ]GRID grid.1002.3, ISNI 0000 0004 1936 7857, Australian and New Zealand Intensive Care Research Centre, , Monash University, ; Melbourne, VIC Australia
                [32 ]GRID grid.475435.4, Department of Intensive Care 4131, , Copenhagen University Hospital Rigshospitalet, ; Copenhagen, Denmark
                [33 ]GRID grid.412590.b, ISNI 0000 0000 9081 2336, University of Michigan Health System, ; Ann Arbor, MI USA
                [34 ]GRID grid.48004.38, ISNI 0000 0004 1936 9764, Liverpool School of Tropical Medicine, ; Liverpool, UK
                [35 ]GRID grid.152326.1, ISNI 0000 0001 2264 7217, Vanderbilt University, ; Nashville, TN USA
                [36 ]GRID grid.62560.37, ISNI 0000 0004 0378 8294, Department of Medicine, Brigham and Women’s Hospital, ; Boston, MA USA
                [37 ]GRID grid.38142.3c, ISNI 000000041936754X, Department of Population Medicine, , Harvard Medical School, and Harvard Pilgrim Health Care Institute, ; Boston, MA USA
                [38 ]GRID grid.267370.7, ISNI 0000 0004 0533 4667, ASAN Medical Center, , University of Ulsan College of Medicine, ; Seoul, South Korea
                [39 ]GRID grid.21613.37, ISNI 0000 0004 1936 9609, University of Manitoba, ; Winnipeg, MB Canada
                [40 ]GRID grid.11194.3c, ISNI 0000 0004 0620 0548, Makerere University College of Health Sciences, ; Kampala, Uganda
                [41 ]GRID grid.419029.7, ISNI 0000 0004 0615 5265, Intensive Care Division, , Faculdade de Medicina de São José do Rio Preto, ; São Paulo, Brazil
                [42 ]GRID grid.410305.3, ISNI 0000 0001 2194 5650, Critical Care Medicine Department, , NIH Clinical Center, ; Bethesda, MD USA
                [43 ]GRID grid.267362.4, ISNI 0000 0004 0432 5259, Alfred Health, ; Melbourne, Australia
                [44 ]GRID grid.416166.2, ISNI 0000 0004 0473 9881, Mount Sinai Hospital, ; Toronto, ON Canada
                [45 ]GRID grid.429252.a, ISNI 0000 0004 1764 4857, Medanta the Medicity, ; Gurugram, Haryana India
                [46 ]GRID grid.11951.3d, ISNI 0000 0004 1937 1135, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, , University of the Witwatersrand, ; Johannesburg, South Africa
                [47 ]GRID grid.137628.9, ISNI 0000 0004 1936 8753, New York University School of Medicine, ; New York, NY USA
                [48 ]GRID grid.4367.6, ISNI 0000 0001 2355 7002, Washington University School of Medicine, ; St. Louis, MO USA
                [49 ]GRID grid.17089.37, Faculty of Nursing, , University of Alberta, ; Edmonton, AB Canada
                [50 ]GRID grid.475435.4, Rigshospitalet, ; Copenhagen, Denmark
                [51 ]GRID grid.17635.36, ISNI 0000000419368657, University of Minnesota/Hennepin County Medical Center, ; Minneapolis, MN USA
                [52 ]GRID grid.1003.2, ISNI 0000 0000 9320 7537, Faculty of Medicine, University of Queensland Centre for Clinical Research, , The University of Queensland, ; Brisbane, Australia
                [53 ]GRID grid.416100.2, ISNI 0000 0001 0688 4634, Department of Pharmacy, , Royal Brisbane and Women’s Hospital, ; Brisbane, Australia
                [54 ]GRID grid.416100.2, ISNI 0000 0001 0688 4634, Department of Intensive Care Medicine, , Royal Brisbane and Women’s Hospital, ; Brisbane, Australia
                [55 ]GRID grid.121334.6, ISNI 0000 0001 2097 0141, Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, , University of Montpellier, ; Nîmes, France
                [56 ]GRID grid.25879.31, ISNI 0000 0004 1936 8972, University of Pennsylvania, ; Philadelphia, PA USA
                [57 ]ChristianaCare, Newark, DE USA
                [58 ]GRID grid.9619.7, ISNI 0000 0004 1937 0538, Faculty of Medicine, , Hebrew University of Jerusalem, ; Jerusalem, Israel
                [59 ]GRID grid.17788.31, ISNI 0000 0001 2221 2926, Department of Anesthesiology, Critical Care and Pain Medicine, , Hadassah Medical Center, ; Jerusalem, Israel
                [60 ]Medizinische Hochschule Hannover and German Center of Lung Research (DZL), Hannover, Germany
                [61 ]World Federation of Intensive and Critical Care, Brussels, Belgium
                [62 ]GRID grid.240588.3, ISNI 0000 0001 0557 9478, Warren Alpert School of Medicine at Brown University, Providence, , Rhode Island & Rhode Island Hospital, ; Providence, RI USA
                Author information
                http://orcid.org/0000-0002-3176-6493
                Article
                6506
                10.1007/s00134-021-06506-y
                8486643
                34599691
                f9fce9d0-7445-4778-b718-74e9ab926189
                © Springer-Verlag GmbH Germany, part of Springer Nature 2021

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 6 June 2021
                : 5 August 2021
                Categories
                Guidelines

                Emergency medicine & Trauma
                sepsis,septic shock,adults,guidelines,evidence based medicine
                Emergency medicine & Trauma
                sepsis, septic shock, adults, guidelines, evidence based medicine

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