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      The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery

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          Abstract

          In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until they reach the target tissue. The ligand on the NP surface recognizes its specific receptor expressed on the target tissue and the drug is released in a controlled manner. However, once injected in a physiological environment, NPs interact with biological components and are surrounded by a protein corona (PC). This can trigger an immune response and affect NP toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the NP–PC interactions and discuss how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.

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          Author and article information

          Journal
          Nanomedicine (Lond)
          Nanomedicine (Lond)
          NNM
          Nanomedicine
          Future Medicine Ltd (London, UK )
          1743-5889
          1748-6963
          January 2016
          11 December 2015
          : 11
          : 1
          : 81-100
          Affiliations
          [1 ]Department of Regenerative Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, 77030 Houston, TX, USA
          [2 ]Fondazione SDN, Via Gianturco 113, 80143 Naples, Italy
          [3 ]CEINGE, Advanced Biotechnology s.c.a.r.l., Via G. Salvatore 486, 80145 Naples, Italy
          Author notes
          *Author for correspondence: ccorbo@ 123456houstonmethodist.org
          Article
          PMC4910943 PMC4910943 4910943
          10.2217/nnm.15.188
          4910943
          26653875
          f9ff04c0-44a4-48ac-94f3-ad0cbf843bf2
          © Future Medicine Ltd
          History
          : 31 July 2015
          : 29 October 2015
          Categories
          Review

          protein corona,immune response,nano–bio interface,nanomedicine,nanoparticles,targeting,toxicity

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