N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury.

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Abstract

The analgesic flupirtine has been linked to cases of severe idiosyncratic drug-induced liver injury (sFILI). We therefore examined whether N-acetylcysteine (NAC) and glucocorticoid therapy is effective in the management of sFILI.

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Journal

Journal ID (iso-abbrev): Liver Int.

Title: Liver international : official journal of the International Association for the Study of the Liver

Publisher: Wiley

ISSN (Electronic): 1478-3231

ISSN (Print): 1478-3223

Publication date (Electronic): February 2018

Volume: 38

Issue: 2

Affiliations

[1 ] Centre for Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany.

[2 ] Section of Hepatology, Clinic for Gastroenterology and Rheumatology, University Hospital Leipzig, Leipzig, Germany.

Article

DOI: 10.1111/liv.13538

PubMed ID: 28782153

SO-VID: fa113c08-69e0-4b48-a2f3-dbcf8b3447e2

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Keywords: flupirtine-induced liver injury,prednisolone,antidote,N-acetylcysteine

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Keywords: flupirtine-induced liver injury, prednisolone, antidote, N-acetylcysteine

N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury.

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