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Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis
William N Whiteley ,
Jonathan Emberson ,
Kennedy R Lees ,
Lisa Blackwell ,
Gregory Albers ,
Erich Bluhmki ,
Thomas Brott ,
Geoff Cohen ,
Stephen Davis ,
Geoffrey Donnan ,
James Grotta ,
George Howard ,
Markku Kaste ,
Masatoshi Koga ,
Rüdiger von Kummer ,
Maarten G Lansberg ,
Richard I Lindley ,
Patrick Lyden ,
Jean Marc Olivot ,
Mark Parsons ,
Danilo Toni ,
Kazunori Toyoda ,
Nils Wahlgren ,
Joanna Wardlaw ,
Gregory J del Zoppo ,
Peter Sandercock ,
Werner Hacke ,
Colin Baigent
August 2016
August 2016
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Abstract
Randomised trials have shown that alteplase improves the odds of a good outcome when
delivered within 4·5 h of acute ischaemic stroke. However, alteplase also increases
the risk of intracerebral haemorrhage; we aimed to determine the proportional and
absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality,
and functional impairment in different types of patients.