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      Applications and grants of National Natural Scientific Foundation of China’s General Program in abnormalities and diseases of locomotor system: a ten-year review

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          Abstract

          Translational medicine is a branch of medical research that attempts to establish a more direct link between basic research and clinical practice. The improvement of clinical management cannot be separated from the progress and breakthrough made in basic biomedical research. As one of the main funding agencies for basic research in China, National Natural Scientific Foundation of China (NSFC) plays an active role in promotion of the development of basic medical research and translational medicine. General Program mainly supports scientists to carry out basic research on bottom-up based topics within the funding scope of NSFC to conduct innovative research and promote a balanced, coordinated and sustained development of all disciplines. Musculoskeletal injury and disease is a major threat to human health worldwide and has become the major cause of disability in China. In this review, we aim to further promote the clinical transformation by summarizing the trends and hotspots of basic research in this field based on the analysis of the data of General Program in abnormalities and diseases of locomotor system over the last decade, including analyses of the number of applications received and projects funded, the distribution of the keywords in applications and grants, distribution of applications and grants of General Program in the secondary application code of H06 and in the host institution.

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          Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

          Summary Background Public health is a priority for the Chinese Government. Evidence-based decision making for health at the province level in China, which is home to a fifth of the global population, is of paramount importance. This analysis uses data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to help inform decision making and monitor progress on health at the province level. Methods We used the methods in GBD 2017 to analyse health patterns in the 34 province-level administrative units in China from 1990 to 2017. We estimated all-cause and cause-specific mortality, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), summary exposure values (SEVs), and attributable risk. We compared the observed results with expected values estimated based on the Socio-demographic Index (SDI). Findings Stroke and ischaemic heart disease were the leading causes of death and DALYs at the national level in China in 2017. Age-standardised DALYs per 100 000 population decreased by 33·1% (95% uncertainty interval [UI] 29·8 to 37·4) for stroke and increased by 4·6% (–3·3 to 10·7) for ischaemic heart disease from 1990 to 2017. Age-standardised stroke, ischaemic heart disease, lung cancer, chronic obstructive pulmonary disease, and liver cancer were the five leading causes of YLLs in 2017. Musculoskeletal disorders, mental health disorders, and sense organ diseases were the three leading causes of YLDs in 2017, and high systolic blood pressure, smoking, high-sodium diet, and ambient particulate matter pollution were among the leading four risk factors contributing to deaths and DALYs. All provinces had higher than expected DALYs per 100 000 population for liver cancer, with the observed to expected ratio ranging from 2·04 to 6·88. The all-cause age-standardised DALYs per 100 000 population were lower than expected in all provinces in 2017, and among the top 20 level 3 causes were lower than expected for ischaemic heart disease, Alzheimer's disease, headache disorder, and low back pain. The largest percentage change at the national level in age-standardised SEVs among the top ten leading risk factors was in high body-mass index (185%, 95% UI 113·1 to 247·7]), followed by ambient particulate matter pollution (88·5%, 66·4 to 116·4). Interpretation China has made substantial progress in reducing the burden of many diseases and disabilities. Strategies targeting chronic diseases, particularly in the elderly, should be prioritised in the expanding Chinese health-care system. Funding China National Key Research and Development Program and Bill & Melinda Gates Foundation.
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            TBX6 null variants and a common hypomorphic allele in congenital scoliosis.

            Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis.
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              Adenomatous polyposis coli and translational medicine.

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                Author and article information

                Journal
                Ann Transl Med
                Ann Transl Med
                ATM
                Annals of Translational Medicine
                AME Publishing Company
                2305-5839
                2305-5847
                August 2020
                August 2020
                : 8
                : 16
                : 1024
                Affiliations
                [1]Department of Health Sciences, National Natural Science Foundation of China , Beijing, China
                Author notes
                Correspondence to: Dou Dou, PhD. Department of Health Sciences, National Natural Science Foundation of China, 83 Shuangqing Road, Beijing, China. Email: doudou@ 123456nsfc.gov.cn .
                Article
                atm-08-16-1024
                10.21037/atm-20-3176
                7475454
                32953824
                fa246efc-b1b5-4c84-ad2f-e4682e5dd86c
                2020 Annals of Translational Medicine. All rights reserved.

                Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

                History
                : 07 April 2020
                : 03 July 2020
                Categories
                Review Article

                national natural scientific foundation of china (nsfc),general program,funding rate,locomotor system

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