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      Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri.

      Journal of Natural Products

      Animals, Babesia, drug effects, Gallic Acid, analogs & derivatives, chemistry, isolation & purification, pharmacology, Gas Chromatography-Mass Spectrometry, Glucose, Glucosides, Indonesia, Inhibitory Concentration 50, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Phyllanthus, Plants, Medicinal, Plasmodium falciparum

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          Abstract

          Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1.4 microg/mL against Plasmodium falciparum in vitro. The known compounds beta-glucogallin (2), quercetin 3-O-beta-d-glucopyranosyl-(2-->1)-O-beta-d-xylopyranoside (3), beta-sitosterol, and gallic acid were also isolated. Structures of these compounds were elucidated on the basis of their chemical and spectroscopic data.

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          Journal
          15844943
          10.1021/np0497245

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