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      Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

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      Cell
      Elsevier BV

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          Abstract

          A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 kDa S6 kinase, mitogen-activated protein kinase (MAPK), phospholipase C-gamma, and the Jak/STAT pathways. The precise role of each of these pathways in cell signaling remains to be resolved, but studies on the differentiation of mammalian PC12 cells in tissue culture and the genetics of cell fate determination in Drosophila and Caenorhabditis suggest that the extracellular signal-regulated kinase (ERK-regulated) MAPK pathway may be sufficient for these cellular responses. Experiments with PC12 cells also suggest that the duration of ERK activation is critical for cell signaling decisions.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          0092-8674
          0092-8674
          Jan 27 1995
          : 80
          : 2
          Affiliations
          [1 ] Chester Beatty Laboratories, Institute of Cancer Research, London, England.
          Article
          0092-8674(95)90401-8
          10.1016/0092-8674(95)90401-8
          7834738
          fa3f74de-017f-412f-9b6d-554a56281c39
          History

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