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      Anterior mediastinal leiomyosarcoma mimicking thymoma : A case report

      case-report
      , MD a , , MD a , , MD b ,
      Medicine
      Wolters Kluwer Health
      CT, imaging, leiomyosarcoma

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          Abstract

          Rationale:

          Mediastinal leiomyosarcoma is very rare. In this paper, we report one case of anterior mediastinal leiomyosarcoma and retrospectively review the imaging findings of previously reported cases.

          Patient Concerns:

          A 61-year-old male patient was admitted to our hospital due to the presence of a mediastinal space-occupying lesion for two years. Two years previously, chest computed tomography (CT) showed a small nodule in the anterior mediastinum. Twenty days previously, the CT examination was repeated at the local hospital due to respiratory symptoms, which showed a mass in the anterior mediastinum and interstitial inflammation of both lungs. After admission to our hospital, chest contrast-enhanced CT scanning showed a mass in the right anterior mediastinum that was approximately 3.3 × 5.2 cm2 in size that had a clear boundary, slightly heterogeneous internal density and heterogeneous enhancement.

          Interventions:

          The patient underwent a mediastinal lump resection.

          Diagnoses:

          Finally, the pathological diagnosis was anterior mediastinal leiomyosarcoma.

          Outcomes:

          The patient recovered well after the operation.

          Lessons:

          Accidental discovery of anterior mediastinal nodules should be followed up. Mediastinal leiomyosarcoma is common in the posterior mediastinum. Imaging shows a heterogeneous mass with a space-occupying effect that may easily involve adjacent mediastinal vessels or infiltrate surrounding organs.

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          Most cited references18

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          Primary thoracic sarcomas.

          Primary sarcomas of the thorax are rare. The diagnosis is established only after sarcomalike primary lung malignancies and metastatic disease have been excluded. Primary sarcomas of the thorax are classified according to their histologic features and constitute a large group of tumors that occur in the lung, mediastinum, pleura, and chest wall. Angiosarcoma, leiomyosarcoma, rhabdomyosarcoma, and mesothelioma (sarcomatoid variant) are the most common primary intrathoracic sarcomas. Ewing sarcoma, primitive neuroectodermal tumor, chondrosarcoma, malignant fibrous histiocytoma, osteosarcoma, synovial sarcoma, and fibrosarcoma usually arise in the chest wall. Although primary thoracic sarcomas commonly manifest as large, heterogeneous masses, they have a wide spectrum of radiologic manifestations, including solitary pulmonary nodules, central endobronchial tumors, and intraluminal masses within the pulmonary arteries. The different histologic types of sarcomas are frequently indistinguishable at radiologic analysis. However, differences in clinical presentation and the location of the tumor, as well as morphologic features such as calcification within the mass and rib involvement, can be useful in suggesting the appropriate diagnosis. For example, a large rib mass in a child with fever and malaise indicates a Ewing sarcoma, a mass with a calcified matrix is likely a chondrosarcoma or osteosarcoma, and a pulmonary artery mass is likely a leiomyosarcoma. Copyright RSNA, 2002
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            Primary sarcomas of the mediastinum: results of therapy.

            Primary sarcomas of the mediastinum are rare, and data concerning treatment and results of therapy are sparse. To assess presentation, management, prognostic factors, and survival in mediastinal sarcomas. We reviewed our experience with 47 patients with the diagnosis of primary sarcoma of the mediastinum. Data were collected from a computerized institutional database and medical records. Survival was analyzed by Kaplan-Meier method and comparisons of survival by log rank test. The median age of 47 patients with mediastinal sarcoma was 39 years (range 2.5 to 69 years), with a male/female ratio of 1.6. The most common complaints were chest/shoulder pain (38%) and dyspnea (23%). The most common tumor types were malignant peripheral nerve tumor (26%), spindle cell sarcoma (15%), leiomyosarcoma (9%), and liposarcoma (9%). Operation was the primary treatment modality in 72% of cases (n = 34); 22 sarcomas (47%) were completely resected. The overall 5-year survival was 32%. High-grade lesions had a significantly decreased survival (5-year survival = 27%) compared with low-grade tumors (5-year survival = 66%) (p = 0.05). The overwhelming factor determining survival was the ability to completely resect the tumors (5-year survival 49% for complete resection; 3-year survival 18% for incomplete or no resection) (p = 0.0016). Despite complete resection, local recurrence occurred in 64% of cases. Because the overall survival for patients with mediastinal sarcomas is 32% and the local recurrence is 64% for tumors completely resected, aggressive adjuvant therapy should continue to be systematically explored.
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              Computed tomography and thymoma: distinctive findings in invasive and noninvasive thymoma and predictive features of recurrence.

              Our goal was to assess the computed tomography (CT) imaging findings of thymoma and to correlate these features with Masaoka staging system and prognosis.
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                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Wolters Kluwer Health
                0025-7974
                1536-5964
                June 2018
                22 June 2018
                : 97
                : 25
                : e11132
                Affiliations
                [a ]Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang
                [b ]Department of Anesthesiology, the First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Taicang, Suzhou, China.
                Author notes
                []Correspondence: Wenjuan Zhang, Department of Anesthesiology, the First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Department and Institution: No. 58, Taicang, Suzhou 215400, China (e-mail: cztchos@ 123456163.com ).
                Article
                MD-D-18-01511 11132
                10.1097/MD.0000000000011132
                6023676
                29924013
                fa418e32-8348-412c-9eb6-84151b0b7596
                Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0

                History
                : 4 March 2018
                : 15 May 2018
                Categories
                6800
                Research Article
                Clinical Case Report
                Custom metadata
                TRUE

                ct,imaging,leiomyosarcoma
                ct, imaging, leiomyosarcoma

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