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Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
N Enomoto
1 ,
I Sakuma ,
Y Asahina ,
M Kurosaki ,
T Murakami ,
C Yamamoto ,
Y Ogura ,
N Izumi ,
F Marumo ,
C Sato
Jan 11 1996
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Abstract
A region associated with sensitivity to interferon has been identified in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. The region spans amino acid residues 2209 to 2248 (NS5A2209-2248) of HCV-J, a strain of HCV-1b whose complete genomic sequence has been identified. We examined whether the NS5A2209-2248 sequence present before therapy could be used as a predictor of the response to interferon therapy in patients with chronic HCV-1b infection.