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      Accumulation of αB-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5′-flanking and coding sequence of the genomic DNA

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      Neuroscience Letters
      Elsevier BV

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          Abstract

          alpha B-Crystallin is a major protein component of Rosenthal fibers, which massively accumulate in the brains of patients suffering from Alexander's disease. To examine whether or not accumulation of alpha B-crystallin is due to any abnormality of the gene structures, we determined the sequence of the alpha B-crystallin gene in two cases of pathologically confirmed Alexander's disease. Direct sequencing of the promoter and coding regions of the alpha B-crystallin gene in patients revealed them to have a normal sequence. Northern blotting showed a single alpha B-crystallin mRNA species expressed in the Alexander's disease brain.

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          Author and article information

          Journal
          Neuroscience Letters
          Neuroscience Letters
          Elsevier BV
          03043940
          June 1992
          June 1992
          : 140
          : 1
          : 89-92
          Article
          10.1016/0304-3940(92)90689-5
          1407707
          fa7205cc-1c2d-4b8d-947b-0f82f09ad41a
          © 1992

          https://www.elsevier.com/tdm/userlicense/1.0/

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