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      Dynamics of Ascorbate in the Aqueous Humor and Tissues Surrounding Ocular Chambers

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          Abstract

          The level of ascorbate in the aqueous humor and surrounding intraocular structures in enucleated arterially perfused rabbit eye was investigated. The enucleated eye preparation was shown to be capable of secreting ascorbate from the perfusate into the aqueous humor. Ascorbate in the iris, ciliary body and cornea was released into the aqueous humor when the eye was perfused with ascorbate-free solution. Failure to obtain aqueous flow rates from the decay of ascorbate in the anterior chamber was due to the contribution of ascorbate from these ocular tissues during the perfusion. Histochemically, ascorbate was localized in the pigmented epithelial layer in the valleys between the ciliary processes and the pars plana of the ciliary body and in the iris. In the cornea, distinct localization of ascorbate was observed in the endothelium and basal cell layer of the epithelium.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1985
          1985
          04 December 2009
          : 17
          : 6
          : 331-337
          Affiliations
          aDepartment of Ophthalmology, Ehime University School of Medicine, Ehime, Japan; bInstitute of Biological Sciences, Oakland University, Rochester, Mich., USA
          Article
          265396 Ophthalmic Res 1985;17:331–337
          10.1159/000265396
          4069569
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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