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The FGF family: biology, pathophysiology and therapy.

Nature reviews. Drug discovery

Animals, therapeutic use, antagonists & inhibitors, Metabolic Syndrome X, metabolism, Humans, Homeostasis, Receptors, Fibroblast Growth Factor, Neoplasms, physiology, Hypophosphatemia, Cardiovascular Diseases, drug therapy, physiopathology, Fibroblast Growth Factors

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      Abstract

      The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.

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      Journal
      19247306
      3684054
      10.1038/nrd2792

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