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      A unique signature identifies a family of zinc-dependent metallopeptidases.

      Febs Letters

      Amino Acid Sequence, Animals, Humans, Metalloendopeptidases, Structure-Activity Relationship

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          Abstract

          The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.

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          Journal
          2914602
          10.1016/0014-5793(89)80471-5

          Chemistry

          Amino Acid Sequence, Animals, Humans, Metalloendopeptidases, Structure-Activity Relationship

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