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MicroRNAs and Xenobiotic Toxicity: An Overview
review-article
Satheeswaran Balasubramanian ,
Kanmani Gunasekaran ,
Saranyadevi Sasidharan ,
Vignesh Jeyamanickavel Mathan ,
Ekambaram Perumal
*
04 May 2020
ADAMTS9, A disintegrin and metalloproteinase with thrombospondin motifs 9,
Ag, Silver,
AHR, Aryl Hydrocarbon Receptor,
Al2O3, Aluminium oxide,
AMPK, Adenosine Monophosphate-activated protein kinase,
ARRB1, Arrestin beta 1,
Au, Gold,
Aβ, Amyloid Beta,
BaP, Benzo[a]pyrene,
BCB, Blood-cerebrospinal fluid barrier,
bcl2l11, B-cell lymphoma-2-like protein 11,
BNIP3−3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3,
CCNB1, Cyclin B1,
CDC25A, M-phase inducer phosphatase 1,
CDC25C, M-phase inducer phosphatase 3,
CDK, Cyclin-dependent Kinase,
CDK1, Cyclin-dependent kinase 1,
CDK6, Cyclin-dependent kinase 6,
CDKN1b, Cyclin-dependent kinase Inhibitor 1B,
CEC, Contaminants of Emerging Concern,
ceRNA, Competing endogenous RNA,
COPD, Chronic obstructive pulmonary disease,
COX2, Cyclooxygenase-2,
CTGF, Connective Tissue Growth Factor,
DGCR8, DiGeorge syndrome chromosomal [or critical] region 8,
DNA, Deoxy ribonucleic acid,
DON, Deoxynivalenol,
ER, Endoplasmic Reticulum,
Fadd, Fas-associated protein with death domain,
Grp78/BIP, Binding immunoglobulin protein,
GTP, Guanosine triphosphate,
Hpf, Hours post fertilization,
HSPA1A, Heat shock 70 kDa protein 1,
IL1R1, Interleukin 1 receptor, type 1,
IL-6, Interleukin 6,
lncRNAs, Long non-coding RNA,
LIN28B, Lin-28 homolog B,
LRP-1-, Low density lipoprotein receptor-related protein 1,
MAPK, Mitogen Activated Protein Kinase,
MC-LR, Microcystin-Leucine Arginine,
MC-RR, Microcystin-Arginine Arginine,
miRNA, MicroRNA,
Mn, Manganese,
MRE, MicroRNA Response Elements,
mRNA, Messenger RNA,
NASH, Non-alcoholic steatohepatitis,
NET1, Neuroepithelial Cell Transforming 1,
NF- ҡB, Nuclear Factor kappa-light-chain-enhancer of activated B cells,
NFKBAP, NFKB Activating protein-1,
NMDAR, N-methyl-d-aspartate receptor,
NPs, Nanoparticles,
Nrf2, Nuclear factor erythroid 2-related factor 2,
PDCD4, Programmed cell death protein 4,
PFAS, Poly-fluoroalkyl substances,
PM2.5, Particulate Matter2.5,
qRT-PCR, quantitative Real Time-Polymerase Chain Reaction,
ripk 1, Receptor-interacting serine/threonine-protein kinase 1,
RISC, RNA-induced silencing complex,
RNAi, RNA interference,
RNA, Ribonucleic acid,
RNase III, Ribonuclease III,
SEMA6D, Semaphorin-6D,
SiO2, Silicon dioxide,
SOLiD, Sequencing by Oligonucleotide Ligation and Detection,
SPIONs, Superparamagnetic Iron Oxide Nanoparticles,
TCDD, 2,3,7,8-Tetrachlorodibenzodioxin,
TNF-α, Tumor necrosis factor – alpha,
TP53, Tumor protein 53,
TRBP, Transactivation Response RNA Binding Protein,
UTR, Untranslated region,
WHO, World Health Organization,
Wnt, Wingless-related integration site,
ZEA, Zearalanone,
Zn, Zinc,
Biomarkers,
Epigenetics,
Environment,
Gene regulation,
Non-coding RNAs,
Toxicity
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Highlights
Abstract
The advent of new technologies has paved the rise of various chemicals that are being employed in industrial as well as consumer products. This leads to the accumulation of these xenobiotic compounds in the environment where they pose a serious threat to both target and non-target species. miRNAs are one of the key epigenetic mechanisms that have been associated with toxicity by modulating the gene expression post-transcriptionally. Here, we provide a comprehensive view on miRNA biogenesis, their mechanism of action and, their possible role in xenobiotic toxicity. Further, we review the recent in vitro and in vivo studies involved in xenobiotic exposure induced miRNA alterations and the mRNA-miRNA interactions. Finally, we address the challenges associated with the miRNAs in toxicological studies.
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Author and article information
adamts9, a disintegrin and metalloproteinase with thrombospondin motifs 9,ag, silver,ahr, aryl hydrocarbon receptor,al2o3, aluminium oxide,ampk, adenosine monophosphate-activated protein kinase,arrb1, arrestin beta 1,au, gold,aβ, amyloid beta,bap, benzo[a]pyrene,bcb, blood-cerebrospinal fluid barrier,bcl2l11, b-cell lymphoma-2-like protein 11,bnip3−3, bcl2/adenovirus e1b 19 kda protein-interacting protein 3,ccnb1, cyclin b1,cdc25a, m-phase inducer phosphatase 1,cdc25c, m-phase inducer phosphatase 3,cdk, cyclin-dependent kinase,cdk1, cyclin-dependent kinase 1,cdk6, cyclin-dependent kinase 6,cdkn1b, cyclin-dependent kinase inhibitor 1b,cec, contaminants of emerging concern,cerna, competing endogenous rna,copd, chronic obstructive pulmonary disease,cox2, cyclooxygenase-2,ctgf, connective tissue growth factor,dgcr8, digeorge syndrome chromosomal [or critical] region 8,dna, deoxy ribonucleic acid,don, deoxynivalenol,er, endoplasmic reticulum,fadd, fas-associated protein with death domain,grp78/bip, binding immunoglobulin protein,gtp, guanosine triphosphate,hpf, hours post fertilization,hspa1a, heat shock 70 kda protein 1,il1r1, interleukin 1 receptor, type 1,il-6, interleukin 6,lncrnas, long non-coding rna,lin28b, lin-28 homolog b,lrp-1-, low density lipoprotein receptor-related protein 1,mapk, mitogen activated protein kinase,mc-lr, microcystin-leucine arginine,mc-rr, microcystin-arginine arginine,mirna, microrna,mn, manganese,mre, microrna response elements,mrna, messenger rna,nash, non-alcoholic steatohepatitis,net1, neuroepithelial cell transforming 1,nf- ҡb, nuclear factor kappa-light-chain-enhancer of activated b cells,nfkbap, nfkb activating protein-1,nmdar, n-methyl-d-aspartate receptor,nps, nanoparticles,nrf2, nuclear factor erythroid 2-related factor 2,pdcd4, programmed cell death protein 4,pfas, poly-fluoroalkyl substances,pm2.5, particulate matter2.5,qrt-pcr, quantitative real time-polymerase chain reaction,ripk 1, receptor-interacting serine/threonine-protein kinase 1,risc, rna-induced silencing complex,rnai, rna interference,rna, ribonucleic acid,rnase iii, ribonuclease iii,sema6d, semaphorin-6d,sio2, silicon dioxide,solid, sequencing by oligonucleotide ligation and detection,spions, superparamagnetic iron oxide nanoparticles,tcdd, 2,3,7,8-tetrachlorodibenzodioxin,tnf-α, tumor necrosis factor – alpha,tp53, tumor protein 53,trbp, transactivation response rna binding protein,utr, untranslated region,who, world health organization,wnt, wingless-related integration site,zea, zearalanone,zn, zinc,biomarkers,epigenetics,environment,gene regulation,non-coding rnas,toxicity
adamts9, a disintegrin and metalloproteinase with thrombospondin motifs 9, ag, silver, ahr, aryl hydrocarbon receptor, al2o3, aluminium oxide, ampk, adenosine monophosphate-activated protein kinase, arrb1, arrestin beta 1, au, gold, aβ, amyloid beta, bap, benzo[a]pyrene, bcb, blood-cerebrospinal fluid barrier, bcl2l11, b-cell lymphoma-2-like protein 11, bnip3−3, bcl2/adenovirus e1b 19 kda protein-interacting protein 3, ccnb1, cyclin b1, cdc25a, m-phase inducer phosphatase 1, cdc25c, m-phase inducer phosphatase 3, cdk, cyclin-dependent kinase, cdk1, cyclin-dependent kinase 1, cdk6, cyclin-dependent kinase 6, cdkn1b, cyclin-dependent kinase inhibitor 1b, cec, contaminants of emerging concern, cerna, competing endogenous rna, copd, chronic obstructive pulmonary disease, cox2, cyclooxygenase-2, ctgf, connective tissue growth factor, dgcr8, digeorge syndrome chromosomal [or critical] region 8, dna, deoxy ribonucleic acid, don, deoxynivalenol, er, endoplasmic reticulum, fadd, fas-associated protein with death domain, grp78/bip, binding immunoglobulin protein, gtp, guanosine triphosphate, hpf, hours post fertilization, hspa1a, heat shock 70 kda protein 1, il1r1, interleukin 1 receptor, type 1, il-6, interleukin 6, lncrnas, long non-coding rna, lin28b, lin-28 homolog b, lrp-1-, low density lipoprotein receptor-related protein 1, mapk, mitogen activated protein kinase, mc-lr, microcystin-leucine arginine, mc-rr, microcystin-arginine arginine, mirna, microrna, mn, manganese, mre, microrna response elements, mrna, messenger rna, nash, non-alcoholic steatohepatitis, net1, neuroepithelial cell transforming 1, nf- ҡb, nuclear factor kappa-light-chain-enhancer of activated b cells, nfkbap, nfkb activating protein-1, nmdar, n-methyl-d-aspartate receptor, nps, nanoparticles, nrf2, nuclear factor erythroid 2-related factor 2, pdcd4, programmed cell death protein 4, pfas, poly-fluoroalkyl substances, pm2.5, particulate matter2.5, qrt-pcr, quantitative real time-polymerase chain reaction, ripk 1, receptor-interacting serine/threonine-protein kinase 1, risc, rna-induced silencing complex, rnai, rna interference, rna, ribonucleic acid, rnase iii, ribonuclease iii, sema6d, semaphorin-6d, sio2, silicon dioxide, solid, sequencing by oligonucleotide ligation and detection, spions, superparamagnetic iron oxide nanoparticles, tcdd, 2,3,7,8-tetrachlorodibenzodioxin, tnf-α, tumor necrosis factor – alpha, tp53, tumor protein 53, trbp, transactivation response rna binding protein, utr, untranslated region, who, world health organization, wnt, wingless-related integration site, zea, zearalanone, zn, zinc, biomarkers, epigenetics, environment, gene regulation, non-coding rnas, toxicity