Double-stranded RNA-dependent protein kinase signalling and paradigms of cardiometabolic syndrome.

Abstract

Metabolic syndrome (Met S) is a collection of the most severe cardiometabolic risk factors that encompasses raised fasting plasma glucose, dyslipidaemia, insulin resistance, obesity and hypertension. The precise mechanism underlying the pathogenesis of Met S remains unclear. More often oxidative stress, inflammation and apoptosis are implicated in its aetiology. Recently, double-stranded RNA-dependent protein kinase has been found to intersect at the cross-road of oxidative stress, inflammation and apoptosis in several metabolic diseases. Therefore, an effort has been made in the present review to discuss the role of double-stranded RNA-dependent protein kinase and above-mentioned mechanisms in the progression of Met S, along with its interlinking in major clinical manifestations of Met S such as hypertension and diabetic cardiomyopathy.