51
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      A characteristic optic disc appearance associated with myopia in subjects with Graves’ ophthalmopathy and in subjects with primary open-angle glaucoma

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          To determine if qualitatively defining the appearance of optic disc change was a valid characteristic of myopia in subjects with Graves’ ophthalmopathy (GO) or primary open-angle glaucoma (POAG).

          Methods

          We defined typical tilt appearance as the simultaneous presence of the following: an elliptical optic disc, a crescent, unequal sharpness of the cupping margin (horizontally), and nasally displaced vessels in the optic cup. Ninety-two eyes from 92 subjects each with GO or with POAG and no severe complications were included in the study after matching for spherical refractive errors. Using our definition of tilt appearance, two independent observers subjectively judged optic disc photographs. One observer repeated judgments in 70 randomly selected eyes and judgment reproducibility was assessed using kappa statistics. Tilt ratio was used as a quantitative parameter.

          Results

          The numbers of eyes judged as having a typical tilt appearance in the GO group and in the POAG group were 25 (27.2%) and 39 (42.4%), respectively, by one observer ( P = 0.0297), and 12 (13%) and 44 (47.8%), respectively, by another observer ( P < 0.0001). Intra- and interobserver reproducibility of tilt judgment were very good (kappa = 0.93) and good (kappa = 0.65), respectively. Tilt ratio did not significantly differ between the two groups. Analytical results including background factors were essentially the same for the two observers: multivariate logistic regression for one observer’s judgment showed that the presence of the typical tilt appearance was associated with belonging to the glaucoma group (odds ratio [OR], 6.25; P = 0.0054), tilt ratio (OR per 0.01, 0.77; P < 0.0001), and spherical refractive error (OR per diopter, 0.80; P < 0.003).

          Conclusion

          The optic disc feature we designated as typical tilt was associated with myopia, and its frequency was higher in subjects with POAG compared to those with GO.

          Related collections

          Author and article information

          Journal
          Clin Ophthalmol
          Clin Ophthalmol
          Clinical Ophthalmology
          Clinical Ophthalmology (Auckland, N.Z.)
          Dove Medical Press
          1177-5467
          1177-5483
          2013
          2013
          07 January 2013
          : 7
          : 47-53
          Affiliations
          [1 ]Yamazaki Eye Clinic, Shinagawa-ku, Tokyo, Japan
          [2 ]Olympia Eye Hospital, Shibuya-ku, Tokyo, Japan
          [3 ]Tsuboi Eye Clinic, Edogawa-ku, Tokyo, Japan
          Author notes
          Correspondence: Sei Yamazaki, Yamazaki Eye Clinic, 1-5-45, Hiratsuka, Shinagawa-ku, Tokyo, 142-0051 Japan, Tel +81 3 3782 6666, Fax +81 3 3782 6651, Email yamazakisei@ 123456gmail.com
          Article
          opth-7-047
          10.2147/OPTH.S39486
          3544351
          23326183
          faa9063b-9e83-4249-8c59-6de6f3619f41
          © 2013 Yamazaki et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          History
          Categories
          Original Research

          Ophthalmology & Optometry
          glaucoma,graves’ ophthalmopathy,myopia,qualitative definition,tilted disc,tilt ratio

          Comments

          Comment on this article