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      Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan.

      American Journal of Public Health
      Adult, Antinematodal Agents, adverse effects, Antitrichomonal Agents, Disease Outbreaks, Female, Humans, Male, Mebendazole, Metronidazole, Occupational Exposure, Odds Ratio, Philippines, ethnology, Risk Factors, Stevens-Johnson Syndrome, chemically induced, etiology, Taiwan, epidemiology

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          Abstract

          This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan. Forty-six SJS/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age. The odds ratio for development of SJS/TEN was 9.5 (95% confidence interval [CI] = 3.9, 23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks. In addition, a gradient increase in the occurrence of SJS/TEN was found with an increasing level of exposure to metronidazole. This outbreak highlights the risk of SJS/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures.

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