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Abstract
Introduction / objectives
To determine the prevalence and the resistance of the extended-spectrum betalactamase
(BLSE) producing enterobacteriacea strains in our hospital.
Methods
All enterobacteriacea strains were screened prospectively between January 2007 and
December 2010 for ESBL on the basis of a positive double disk synergy test or positive
Ceftazidime and Cefotaxime clavulanic acid combination disks tests. To detect ESBL
in the species producing Ampc Betalactamase a modified double disk diffusion test
(MDDT) by Pitout et al. was used.
Results
Among 979 strains isolated during this period, 10.82 % (106) were ESBL producers.
These bacteria were isolated in 94.33% in the inpatients specimens. Their distribution
was essentially in the ICU (22.64%),the surgery (20.75%) and the pediatrics 21.21%.They
were more frequently isolated from urines (36.79%), pus (33%), peritoneal liquid (15,15%)and
bacteremia (12,26%).This betalactamase was produced by Klebsiella pneumoniae in 60.37%,
EÂ .coli in 21.69% Enterobacter cloacae in 15% . Klebsiella, EÂ .coli and Enterobacter
cloacae were also resistant to Fluoroquinolone (28.12%, 34.78% and 31.25%), aminoglycoside
(71.8%,56.52% and 50%) and Cotrimoxazole (28.12%,30.43% and 31.25%).
Conclusion
This study showed that the ESBL producing enterobacteria strains rate is high in our
hospital. Other strain than Klebsiella and E.coli are expressing ESBL .It is the case
of Enterobacter cloacae . So we have to perform the detection of these strains in
our laboratory, because these bacteria may function as a reservoir for plasmids carrying
ESBL-encoding genes. In front of this situation we have to enhance the hygiene measures
in the units were these strains were isolated to limit their diffusion.
Disclosure of interest
None declared.
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Conference name:
International Conference on Prevention & Infection Control (ICPIC 2011)