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      Applications of Anterior Segment Optical Coherence Tomography in Cornea and Ocular Surface Diseases

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          Abstract

          Optical coherence tomography (OCT) is a noncontact technology that produces high-resolution cross-sectional images of ocular tissues. Anterior segment OCT (AS-OCT) enables the precise visualization of anterior segment structure; thus, it can be used in various corneal and ocular surface disorders. In this review, the authors will discuss the application of AS-OCT for diagnosis and management of various corneal and ocular surface disorders. Use of AS-OCT for anterior segment surgery and postoperative management will also be discussed. In addition, application of the device for research using human data and animal models will be introduced.

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          Optical coherence tomography.

          D. Huang, E Swanson, C. Lin … (1991)
          A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
          Article 0 comments Cited 748 times – based on 0 reviews     Review now
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            Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography.

            Joseph A. Izatt, Songping D. Huang, J Fujimoto … (1994)
            To demonstrate a new diagnostic technique, optical coherence tomography, for high-resolution cross-sectional imaging of structures in the anterior segment of the human eye in vivo. Optical coherence tomography is a new, noninvasive, noncontact optical imaging modality that has spatial resolution superior to that of conventional clinical ultrasonography ( 90 dB). Survey of intraocular structure and dimension measurements. Laboratory. Convenience sample. Correlation with range of accepted normal intraocular structure profiles and dimensions. Direct in vivo measurements with micrometer-scale resolution were performed of corneal thickness and surface profile (including visualization of the corneal epithelium), anterior chamber depth and angle, and iris thickness and surface profile. Dense nuclear cataracts were successfully imaged through their full thickness in a cold cataract model in calf eyes in vitro. Optical coherence tomography has potential as a diagnostic tool for applications in noncontact biometry, anterior chamber angle assessment, identification and monitoring of intraocular masses and tumors, and elucidation of abnormalities of the cornea, iris, and crystalline lens.
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              Real-time optical coherence tomography of the anterior segment at 1310 nm.

              S. Radhakrishnan, A. Rollins, J. E. Roth … (2001)
              Recent advances in high-speed scanning technology have enabled a new generation of optical coherence tomographic (OCT) systems to perform imaging at video rate. Here, a handheld OCT probe capable of imaging the anterior segment of the eye at high frame rates is demonstrated for the first time. To demonstrate real-time OCT imaging of anterior segment structures. Survey of anterior segment structures in normal human subjects. Laboratory. Achieving real-time imaging of the anterior segment, satisfactory image quality, and convenience of a handheld probe. Optical coherence tomographic imaging of the anterior segment of the eyes of human subjects was performed using 1310-nm wavelength light with an image rate of 8 frames per second. Imaging trials demonstrated clear resolution of corneal epithelium and stroma, sclerocorneal junction, sclera, iris pigment epithelium and stroma, and anterior lens capsule. The anterior chamber angle was clearly visualized. Limited imaging of the ciliary body was performed. Real-time imaging of pupillary constriction in response to light stimulus was also performed. High-speed OCT at 1310-nm wavelength is a potentially useful technique for noninvasive assessment of anterior segment structures. Our results suggest that real-time OCT has potential applications in glaucoma evaluation and refractive surgery.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Ophthalmol
                Journal ID (iso-abbrev): J Ophthalmol
                Journal ID (publisher-id): JOPH
                Title: Journal of Ophthalmology
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 2090-004X
                ISSN (Electronic): 2090-0058
                Publication date (Print): 2016
                Publication date (Electronic): 19 September 2016
                Volume: 2016
                Electronic Location Identifier: 4971572
                Affiliations
                1Department of Ophthalmology, Kangwon National University Hospital, Seoul, Republic of Korea
                2Singapore National Eye Centre, Singapore
                3Singapore Eye Research Institute, Singapore
                4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
                5Department of Ophthalmology, Autonomous University of Nuevo Leon, Monterrey, NL, Mexico
                Author notes
                *Jodhbir S. Mehta: jodmehta@ 123456gmail.com

                Academic Editor: Tamer A. Macky

                Author information
                http://orcid.org/0000-0001-6362-4898
                Article
                DOI: 10.1155/2016/4971572
                PMC ID: 5046038
                PubMed ID: 27721988
                SO-VID: fac15551-d877-43c7-bf27-1ca2520b8ad8
                Copyright © Copyright © 2016 Sang Beom Han et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 16 June 2016
                Date accepted : 31 July 2016
                Funding
                Funded by: Kangwon National University Hospital
                Categories
                Subject: Review Article

                ScienceOpen disciplines: Ophthalmology & Optometry
                Data availability:
                ScienceOpen disciplines: Ophthalmology & Optometry

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