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      Studies on the Mechanism of the Venoconstrictor Activity of Ergotamine on Isolated Canine Saphenous Veins


      Journal of Vascular Research

      S. Karger AG

      Veins, Ergotamine, α-Adrenoceptors

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          Ergotamine stimulates spiral strips from dog saphenous veins in concentrations about 2,000 times lower than that of noradrenaline, but its maximal effect is only 20% compared to that of noradrenaline. Phentolamine antagonizes the ergotamine effects. The pA<sub>2</sub> value for phentolamine against ergotamine is 6.94, and for phentolamine against noradrenaline it is 6.96. Cocaine potentiates noradrenaline effects but does not change ergotamine effects. The results suggest that the venoconstrictor activity of ergotamine is mediated mainly via stimulation of α-adrenoceptors.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 11
          : 3
          : 183-190
          Biological and Medical Research Division, Sandoz Ltd., Basel
          158011 Blood Vessels 1974;11:183–190
          © 1974 S. Karger AG, Basel

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          Pages: 8
          Research Paper


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