Studies on the Mechanism of the Venoconstrictor Activity of Ergotamine on Isolated Canine Saphenous Veins

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Abstract

Ergotamine stimulates spiral strips from dog saphenous veins in concentrations about 2,000 times lower than that of noradrenaline, but its maximal effect is only 20% compared to that of noradrenaline. Phentolamine antagonizes the ergotamine effects. The pA<sub>2</sub> value for phentolamine against ergotamine is 6.94, and for phentolamine against noradrenaline it is 6.96. Cocaine potentiates noradrenaline effects but does not change ergotamine effects. The results suggest that the venoconstrictor activity of ergotamine is mediated mainly via stimulation of α-adrenoceptors.

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Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 18 September 2008

Volume: 11

Issue: 3

Pages: 183-190

Affiliations

Biological and Medical Research Division, Sandoz Ltd., Basel

Article

Publisher ID: 158011 Other ID: Blood Vessels 1974;11:183–190

DOI: 10.1159/000158011

SO-VID: faf1e6ae-24e5-4e86-95e1-4219f4e71122

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 11 February 1974

Date accepted : 12 June 1974

Page count

Pages: 8

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Studies on the Mechanism of the Venoconstrictor Activity of Ergotamine on Isolated Canine Saphenous Veins

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Abstract

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Karger: Cardiovascular System

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