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      Increased Cytokine Gene Expression in Rat Retina following Transient Ischemia

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          Tumor necrosis factor (TNF) gene expression in rat retina following transient ischemia was studied by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Gene expression for other cytokines was also studied by RT-PCR. Although very little expression for TNF gene was detected in normal retina, it was markedly increased 0.5-48 h after reperfusion, with peak expression at 12 h (20-fold of control). Gene expression for interleukin-6, interferon-γ, and transforming growth factor-β<sub>1</sub> was also increased. The results provide evidence that retinal ischemia can up-regulate cytokine gene expression in the retina.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 28
          : 4
          : 248-254
          aDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto; bDepartment of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan
          267910 Ophthalmic Res 1996;28:248–254
          © 1996 S. Karger AG, Basel

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