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      • Record: found
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      • Article: found

      Increased Cytokine Gene Expression in Rat Retina following Transient Ischemia

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          Abstract

          Tumor necrosis factor (TNF) gene expression in rat retina following transient ischemia was studied by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Gene expression for other cytokines was also studied by RT-PCR. Although very little expression for TNF gene was detected in normal retina, it was markedly increased 0.5-48 h after reperfusion, with peak expression at 12 h (20-fold of control). Gene expression for interleukin-6, interferon-γ, and transforming growth factor-β<sub>1</sub> was also increased. The results provide evidence that retinal ischemia can up-regulate cytokine gene expression in the retina.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1996
          Publication date (Print): 1996
          Publication date (Electronic): 11 December 2009
          Volume: 28
          Issue: 4
          Pages: 248-254
          Affiliations
          aDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto; bDepartment of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan
          Article
          Publisher ID: 267910 Other ID: Ophthalmic Res 1996;28:248–254
          DOI: 10.1159/000267910
          PubMed ID: 8878188
          SO-VID: faf7a733-316e-4020-aa9d-5bad15f6eeea
          Copyright © © 1996 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 24 July 1995
          Date accepted : 04 January 1996
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Ischemia-reperfusion,Rat retina,Reverse transcription-polymerase chain reaction,Tumor necrosis factor Interleukin-6 Interferon-&gamma;,Transforming growth factor-&beta;1 Cytokine
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Ischemia-reperfusion, Rat retina, Reverse transcription-polymerase chain reaction, Tumor necrosis factor Interleukin-6 Interferon-&gamma;, Transforming growth factor-&beta;1 Cytokine

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