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      Maintenance and expression of the S. cerevisiae mitochondrial genome—From genetics to evolution and systems biology

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      Biochimica et Biophysica Acta (BBA) - Bioenergetics
      Elsevier BV

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          Abstract

          As a legacy of their endosymbiotic eubacterial origin, mitochondria possess a residual genome, encoding only a few proteins and dependent on a variety of factors encoded by the nuclear genome for its maintenance and expression. As a facultative anaerobe with well understood genetics and molecular biology, Saccharomyces cerevisiae is the model system of choice for studying nucleo-mitochondrial genetic interactions. Maintenance of the mitochondrial genome is controlled by a set of nuclear-coded factors forming intricately interconnected circuits responsible for replication, recombination, repair and transmission to buds. Expression of the yeast mitochondrial genome is regulated mostly at the post-transcriptional level, and involves many general and gene-specific factors regulating splicing, RNA processing and stability and translation. A very interesting aspect of the yeast mitochondrial system is the relationship between genome maintenance and gene expression. Deletions of genes involved in many different aspects of mitochondrial gene expression, notably translation, result in an irreversible loss of functional mtDNA. The mitochondrial genetic system viewed from the systems biology perspective is therefore very fragile and lacks robustness compared to the remaining systems of the cell. This lack of robustness could be a legacy of the reductive evolution of the mitochondrial genome, but explanations involving selective advantages of increased evolvability have also been postulated. Copyright © 2009 Elsevier B.V. All rights reserved.

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          Author and article information

          Journal
          Biochimica et Biophysica Acta (BBA) - Bioenergetics
          Biochimica et Biophysica Acta (BBA) - Bioenergetics
          Elsevier BV
          00052728
          June 2010
          June 2010
          : 1797
          : 6-7
          : 1086-1098
          Article
          10.1016/j.bbabio.2009.12.019
          20056105
          fafa6bb0-8240-406b-ab33-95e95e3da4a6
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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