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      Estrogen Deficiency and Risk of Alzheimer's Disease in Women

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      American Journal of Epidemiology
      Oxford University Press (OUP)

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          Abstract

          The authors explored the possibility that estrogen loss associated with menopause may contribute to the development of Alzheimer's disease by using a case-control study nested within a prospective cohort study. The Leisure World Cohort includes 8,877 female residents of Leisure World Laguna Hills, a retirement community in southern California, who were first mailed a health survey in 1981. From the 2,529 female cohort members who died between 1981 and 1992, the authors identified 138 with Alzheimer's disease or other dementia diagnoses likely to represent Alzheimer's disease (senile dementia, dementia, or senility) mentioned on the death certificate. Four controls were individually matched by birth date (+/- 1 year) and death date (+1 year) to each case. The risk of Alzheimer's disease and related dementia was less in estrogen users relative to nonusers (odds ratio = 0.69, 95 percent confidence interval 0.46-1.03). The risk decreased significantly with increasing estrogen dose and with increasing duration of estrogen use. Risk was also associated with variables related to endogenous estrogen levels; it increased with increasing age at menarche and (although not statistically significant) decreased with increasing weight. This study suggests that the increased incidence of Alzheimer's disease in older women may be due to estrogen deficiency and that estrogen replacement therapy may be useful for preventing or delaying the onset of this dementia.

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          Author and article information

          Journal
          American Journal of Epidemiology
          Oxford University Press (OUP)
          1476-6256
          0002-9262
          August 01 1994
          August 01 1994
          August 01 1994
          August 01 1994
          August 01 1994
          August 01 1994
          : 140
          : 3
          : 256-261
          Article
          10.1093/oxfordjournals.aje.a117244
          8030628
          fb027a72-8ca1-45a2-a130-ddbd956c3b3d
          © 1994
          History

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