Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients.

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Abstract

Adenosine 5'-triphosphate (ATP) stimulates pulmonary vagal slow conducting C-fibres and fast conducting Aδ-fibres with rapidly adapting receptors (RARs). Pulmonary C-fibres but not RARs are also sensitive to capsaicin, a potent tussigenic agent in humans. Thus, the aim of this study was to determine the effects of ATP and its metabolite adenosine (given as adenosine 5'-monophosphate, AMP) on capsaicin challenge in asthmatic patients.

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Journal

Journal ID (iso-abbrev): Pulm Pharmacol Ther

Title: Pulmonary pharmacology & therapeutics

Publisher: Elsevier BV

ISSN (Electronic): 1522-9629

ISSN (Print): 1094-5539

Publication date (Electronic): Aug 2017

Volume: 45

Affiliations

[1 ] Department of Chest Diseases, Ege University Faculty of Medicine, Izmir, Turkey.

[2 ] Drexel University, College of Medicine, Department of Medicine, Philadelphia, PA, USA. Electronic address: apelleg@drexelmed.edu.

[3 ] Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK.

Article

Publisher Item ID: S1094-5539(16)30133-X

DOI: 10.1016/j.pupt.2017.04.004

PubMed ID: 28392320

SO-VID: fb1dede3-b361-458b-80d3-031de15ee2b1

History

Keywords: Asthma,Cough,Puirinergic receptors,Vagus

Data availability:

Keywords: Asthma, Cough, Puirinergic receptors, Vagus

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