Objective: To explore the relationship between patient-reported outcomes (PRO) and clinical objective indicators in stroke patients.
Methods: One hundred inpatients diagnosed with stroke and received treatment in Department of Neurology, First Affiliated Hospital of Kunming Medical University from May 2010 to March 2011 were selected as the subjects, and SF-36 Scale was used to measure their PRO. The clinical objective indicators measured on the second day after admission were collected from the medical records, including albumin, globulin, urea, fasting blood glucose, blood potassium, platelet count, activated partial thromboplastin time, and degree of education. The correlation between PRO and clinical objective indicators was analyzed by simple correlation and canonical correlation.
Results: Simple correlation analysis showed that globulin was negatively correlated with bodily pain (BP), vitality (VT) (P<0.05) ; urea was negatively correlated with physical functioning (PF) (P<0.05) ; fasting blood glucose was negatively correlated with general health perceptions (GH) (P<0.05) ; blood potassium was negatively correlated with PF (P<0.05) ; platelet count was negatively correlated with PF (P<0.05) ; educational level was positively correlated with PF, BP, VT, and emotional role functioning (RE) (P<0.05). Canonical correlation analysis showed that canonical variables (μ1, ν1), (μ2, ν2) existed correlation (r=0.536 0, r=0.325 6, P<0.05). Canonical variable coefficient of globulin and μ1 was -0.832 2, canonical variable coefficient of activated partial thromboplastin time and μ1was 0.358 5; canonical variable coefficient of platelet count and μ2 was 0.581 6, canonical variable coefficient of educational level and μ2 was 0.672 0; canonical variable coefficient of VT and ν1 was 1.061 7, canonical variable coefficient of mental health (MH) and ν1 was -0.761 8, canonical variable coefficient of PF and ν2 was -0.950 1, canonical variable coefficient of GH and ν2 was 0.443 8. Globulin was highly negatively correlated with μ1 (r=-0.835 0, P<0.05). PF was highly negatively correlated with ν2 (r=-0.738 6, P<0.05). VT was highly positively correlated with ν1 (r=0.727 2, P<0.05).
Conclusion: Clinical objective indicators correlate with PROs in stroke patients. Therefore, taking interventions based on the values of these indicators is of some significance in improving the PROs of these patients.