Serum Ferritin and Hemochromatosis Alleles in Chronic Hemodialysis Patients

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Abstract

There have been some reports on the risk of developing hemosiderosis in hemodialysis patients when heavily transfused and simultaneously possessing hemochromatosis alleles (HA). We evaluated 99 patients on chronic hemodialysis estimating their serum ferritin (SF) levels, transfusion rate, and prevalence of HLA A3, B7 and B14 alleles, which are considered to be more frequent in idiopathic hemochromatosis. We analyzed the patients as a whole group and also separately as low or high transfusion groups. There was no correlation between the number of HA and the mean SF levels. The presence of HA is not a risk factor for the development of hemosiderosis when excessive transfusions and parenteral iron administration are avoided.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1988

Publication date (Print): 1988

Publication date (Electronic): 09 December 2008

Volume: 50

Issue: 3

Pages: 196-198

Affiliations

Department of Nephrology, Hospital de Santa Cruz, Carnaxide, Portugal

Article

Publisher ID: 185157 Other ID: Nephron 1988;50:196–198

DOI: 10.1159/000185157

PubMed ID: 3226455

SO-VID: fb4d5c9c-425f-4d19-bfaf-22ffc09d2135

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Serum Ferritin and Hemochromatosis Alleles in Chronic Hemodialysis Patients

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Karger: Nephrology

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