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      Una justificación del deber de investigar: COVID-19, derecho a la ciencia y obligaciones distributivas Translated title: A justification for the duty to research: COVID-19, right to science and distributive obligations Translated title: Una justificació del deure d'investigar: COVID-19, dret a la ciència i obligacions distributives

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          Abstract

          Resumen En este artículo, daré una justificación del deber de investigar que tienen los Estados durante los contextos de emergencia de salud pública, en este caso por la pandemia provocada por el SARS-CoV-2. Además, defenderé que este deber de investigar se corresponde con el derecho a la ciencia en tiempos normales, y en tiempos de emergencia también con el derecho a la salud, y detallaré qué obligaciones se derivan. Finalmente, intentaré responder algunas objeciones relativas a la investigación con seres humanos en tiempo de pandemias, a saber, la impermisibilidad moral de la investigación, la pérdida de tiempo al investigar en pandemia, la minimización de estándares en contextos de emergencia y la irrelevancia estatal.

          Translated abstract

          Abstract In this article, I will provide a justification for the duty to research that States have during public health emergencies, in this case due to the SARS-CoV-2 pandemic. Furthermore, I will defend that this duty to research follows from the right to science in normal times, and in times of emergency also stems from the right to health, and I will detail what obligations arise. Finally, I will try to answer some objections related to research on human beings in times of pandemics namely moral impermissibility of research, the waste of time when researching in a pandemic, the minimization of scientific standards in emergency contexts, and the irrelevance of the state.

          Translated abstract

          Resum En aquest article, donaré una justificació del deure d'investigar que tenen els Estats durant els contextos d'emergència de salut pública, en aquest cas per la pandèmia provocada pel SARS-CoV-2. A més, defensaré que aquest deure d'investigar es correspon amb el dret a la ciència en temps normals, i en temps d'emergència també amb el dret a la salut, i detallaré quines obligacions es deriven. Finalment, intentaré respondre algunes objeccions relatives a la recerca amb éssers humans en temps de pandèmies, a saber, la impermissibilitat moral de la recerca, la pèrdua de temps en investigar en pandèmia, la minimització d'estàndards en contextos d'emergència i la irrellevància estatal.

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          Most cited references29

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          Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

          The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. However, to our knowledge, it has not been reported that patients with COVID-19 had any neurologic manifestations.
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            Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

            The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People's Hospital for centralized isolation in accordance with policy1. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15-26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6-10.7) were significantly lower (P = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8-38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.
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              Against pandemic research exceptionalism

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                Author and article information

                Journal
                bioetica
                Revista de Bioética y Derecho
                Rev. Bioética y Derecho
                Observatori de Bioètica i Dret - Cátedra UNESCO de Bioética (Barcelona, Barcelona, Spain )
                1886-5887
                2021
                : 51
                : 5-20
                Affiliations
                [1] orgnameUniversidad de Buenos Aires Argentina
                [3] orgnameFLACSO Argentina
                [2] orgnameUniversidad de Buenos Aires orgdiv1Instituto de Investigaciones Jurídicas y Sociales Ambrosio Lucas Gioja Argentina
                Article
                S1886-58872021000100002 S1886-5887(21)00005100002
                fb5a0fd9-8a6a-4ad8-a876-71be6bcf5ec8

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 01 July 2020
                : 14 September 2020
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 29, Pages: 16
                Product

                SciELO Spain

                Categories
                Perspectivas Bioéticas

                recerca clínica,Right to science,recerca en context d'emergència de salut pública,clinical research,ètica de la recerca,COVID-19,deure d'investigar responsablement,deber de investigar responsablemente,dret a la ciència,ética de la investigación,investigación en contexto de emergencia de salud pública,research in the context of a public health emergency,investigación clínica,research ethics,duty to research,derecho a la ciencia

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