Health-related quality of life and its predictors among patients with breast cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

Breast cancer is the second most prevalent malignancy in Ethiopia and severely affects patients’ health-related quality of life (HRQOL). We aimed to assess HRQoL, factors influencing HRQoL, and utilities among breast cancer patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.

Methods

A hospital-based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital from December 2017 to February, 2018. A total of 404 breast cancer patients were interviewed using the validated Amharic version of the European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), EORTC QLQ-BR23, and Euro Quality of Life Group’s 5-Domain Questionnaires 5 Levels (EQ-5D-5 L) instruments. Mean scores and mean differences of EORTC- QLQ-C30 and EORTC- QLQ-BR23 were calculated. One-way ANOVA test was employed to determine the significance of mean differences among dependent and independent variables while stepwise multivariate logistic regression was used to identify factors associated with the global quality of life (GQOL). Coefficients and level specific utility values obtained from a hybrid regression model for the Ethiopian population were used to compute utility values of each health state. Data was analyzed using SPSS version 23.

Results

The mean age of patients was 43.94 ± 11.72 years. The mean score for GQoL and visual analog scale was 59.32 ± 22.94 and 69.94 ± 20.36, respectively while the mean utility score was 0.8 ± 0.25. Predictors of GQoL were stage of cancer (AOR = 7.94; 95% CI: 1.83–34.54), cognitive functioning (AOR = 2.38; 95% CI: 1.32–4.31), pain (AOR = 7.99; 95% CI: 4.62–13.83), financial difficulties (AOR = 2.60; 95% CI: 1.56–4.35), and future perspective (AOR = 2.08; 95% CI: 1.24–3.49).

Conclusions

The overall GQoL of breast cancer patients was moderate. Targeted approaches to improve patients’ HRQoL should consider stage of cancer, cognitive functioning, pain, financial status and worries about the patient’s future health. This study also provides estimates of EQ-5D utility scores that can be used in economic evaluations.

Related collections

Most cited references 24

Record: found
Abstract: found
Article: found

Is Open Access

Breast cancer screening in developing countries

René Aloisio da Costa Vieira, Gabriele Biller, Gilberto Uemura … (2017)

Developing countries have limited healthcare resources and use different strategies to diagnose breast cancer. Most of the population depends on the public healthcare system, which affects the diagnosis of the tumor. Thus, the indicators observed in developed countries cannot be directly compared with those observed in developing countries because the healthcare infrastructures in developing countries are deficient. The aim of this study was to evaluate breast cancer screening strategies and indicators in developing countries. A systematic review and the Population, Intervention, Comparison, Outcomes, Timing, and Setting methodology were performed to identify possible indicators of presentation at diagnosis and the methodologies used in developing countries. We searched PubMed for the terms “Breast Cancer” or “Breast Cancer Screening” and “Developing Country” or “Developing Countries”. In all, 1,149 articles were identified. Of these articles, 45 full articles were selected, which allowed us to identify indicators related to epidemiology, diagnostic intervention (diagnostic strategy, diagnostic infrastructure, percentage of women undergoing mammography), quality of intervention (presentation of symptoms at diagnosis, time to diagnosis, early stage disease), comparisons (trend curves, subpopulations at risk) and survival among different countries. The identification of these indicators will improve the reporting of methodologies used in developing countries and will allow us to evaluate improvements in public health related to breast cancer.

0 comments Cited 90 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study

Ali Montazeri, Mariam Vahdaninia, Iraj Harirchi … (2008)

Background Measuring quality of life in breast cancer patients is of importance in assessing treatment outcomes. This study examined the impact of breast cancer diagnosis and its treatment on quality of life of women with breast cancer. Methods This was a prospective study of quality of life in breast cancer patients. Quality of life was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its breast cancer supplementary measure (QLQ-BR23) at three points in time: baseline (pre diagnosis), three months after initial treatment and one year after completion of treatment (in all 18 months follow-up). At baseline the questionnaires were administered to all suspected identified patients while both patients and the interviewer were blind to the final diagnosis. Socio-demographic and clinical data included: age, education, marital status, disease stage and initial treatment. Repeated measure analysis was performed to compare quality of life differences over the time. Results In all, 167 patients diagnosed with breast cancer. The mean age of breast cancer patients was 47.2 (SD = 13.5) years and the vast majority (82.6%) underwent mastectomy. At eighteen months follow-up data for 99 patients were available for analysis. The results showed there were significant differences in patients' functioning and global quality of life at three points in time (P < 0.001). Although there were deteriorations in patients' scores for body image and sexual functioning, there were significant improvements for breast symptoms, systematic therapy side effects and patients' future perspective (P < 0.05). Conclusion The findings suggest that overall breast cancer patients perceived benefit from their cancer treatment in long-term. However, patients reported problems with global quality of life, pain, arm symptoms and body image even after 18 months following their treatments. In addition, most of the functional scores did not improve.

0 comments Cited 69 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Cognitive Impairment Associated with Cancer: A Brief Review.

J. Cara Pendergrass, Steven D Targum, John E. Harrison (2018)

This brief review explores the areas of cognitive impairment that have been observed in cancer patients and survivors, the cognitive assessment tools used, and the management of the observed cognitive changes. Cognitive changes and impairment observed in patients with cancer and those in remission can be related to the direct effects of cancer itself, nonspecific factors or comorbid conditions that are independent of the actual disease, and/or the treatments or combination of treatments administered. Attention, memory, and executive functioning are the most frequently identified cognitive domains impacted by cancer. However, the prevalence and extent of impairment remains largely unknown due to marked differences in methodology, definitions of cognitive impairment, and the assessment measures used. Assessment of cognitive functioning is an important and necessary part of a comprehensive oncological care plan. Research is needed to establish a better understanding of cognitive changes and impairments associated with cancer so that optimal patient outcomes can be achieved.

0 comments Cited 60 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Selamawit Gebrehiwot Sibhat: Selamsgsb@gmail.com

Teferi Gedif Fenta: tgedif@gmail.com

Beate Sander: beate.sander@uhnresearch.ca

Gebremedhin Beedemariam Gebretekle:

ORCID: http://orcid.org/0000-0002-2485-505X

+251912198210 , gebremedhin.beedemariam@aau.edu.et

Journal

Journal ID (nlm-ta): Health Qual Life Outcomes

Journal ID (iso-abbrev): Health Qual Life Outcomes

Title: Health and Quality of Life Outcomes

Publisher: BioMed Central (London )

ISSN (Electronic): 1477-7525

Publication date (Electronic): 5 November 2019

Publication date PMC-release: 5 November 2019

Publication date Collection: 2019

Volume: 17

Electronic Location Identifier: 165

Affiliations

[1 ]ISNI 0000 0001 1250 5688, GRID grid.7123.7, School of Pharmacy, College of Health Sciences, , Addis Ababa University, ; Zambia Street, Addis Ababa, Ethiopia

[2 ]ISNI 0000 0001 2157 2938, GRID grid.17063.33, Institute of Health Policy, Management and Evaluation, , University of Toronto, ; Toronto, Canada

[3 ]ISNI 0000 0004 0474 0428, GRID grid.231844.8, Toronto Health Economics and Technology Assessment (THETA) Collaborative, , University Health Network, ; Toronto, Canada

[4 ]ISNI 0000 0001 1505 2354, GRID grid.415400.4, Public Health Ontario, ; Toronto, Ontario Canada

Author information

Gebremedhin Beedemariam Gebretekle http://orcid.org/0000-0002-2485-505X

Article

Publisher ID: 1239

DOI: 10.1186/s12955-019-1239-1

PMC ID: 6833153

PubMed ID: 31690327

SO-VID: fb6009c8-3d97-49d8-b1ae-14f2ee2e3ef3

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 22 May 2019

Date accepted : 24 October 2019

Funding

Funded by: Addis Ababa University, School of Graduate Studies

Award ID: lamp-sum money given to all postgraduate students

Award Recipient : Selamawit Gebrehiwot Sibhat

Custom metadata

ScienceOpen disciplines: Health & Social care

Keywords: breast cancer,health-related quality of life,hrqol,eortc-qlq-c30,eortc-qlq-br23,eq5d,utility

Data availability:

ScienceOpen disciplines: Health & Social care

Keywords: breast cancer, health-related quality of life, hrqol, eortc-qlq-c30, eortc-qlq-br23, eq5d, utility

Health-related quality of life and its predictors among patients with breast cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Read this article at

Abstract

Background

Methods

Results

Conclusions

Related collections

Tobacco Prevention & Cessation

Most cited references 24

Breast cancer screening in developing countries

Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study

Cognitive Impairment Associated with Cancer: A Brief Review.

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 303

Cited by 12

Most referenced authors 561