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      A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

      1 , 2 , 3 , 4
      Clinical Microbiology Reviews
      American Society for Microbiology

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          Abstract

          SUMMARY

          Hantaviruses are enzootic viruses that maintain persistent infections in their rodent hosts without apparent disease symptoms. The spillover of these viruses to humans can lead to one of two serious illnesses, hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. In recent years, there has been an improved understanding of the epidemiology, pathogenesis, and natural history of these viruses following an increase in the number of outbreaks in the Americas. In this review, current concepts regarding the ecology of and disease associated with these serious human pathogens are presented. Priorities for future research suggest an integration of the ecology and evolution of these and other host-virus ecosystems through modeling and hypothesis-driven research with the risk of emergence, host switching/spillover, and disease transmission to humans.

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          Author and article information

          Journal
          Clinical Microbiology Reviews
          CMR
          American Society for Microbiology
          0893-8512
          1098-6618
          April 2010
          April 2010
          : 23
          : 2
          : 412-441
          Affiliations
          [1 ] Department of Microbiology and Immunology
          [2 ] the Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky
          [3 ] Virology Research Center, School of Medicine of the University of São Paulo, Ribeirão Preto City, São Paulo, Brazil
          [4 ] Department of Virology, Haartman Institute, and Department of Basic Veterinary Sciences, University of Helsinki, HUSLAB, Helsinki, Finland
          Article
          10.1128/CMR.00062-09
          2863364
          20375360
          fb7059e5-568b-4a77-bddc-f2e18c024c23
          © 2010
          History

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