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      Use of Psychotropic Medication in Victims of Sudden Cardiac Death with Nonischemic Heart Disease

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          Abstract

          Background: Nonischemic heart disease (NIHD) is the underlying pathology in about 20% of sudden cardiac deaths (SCDs). Psychotropic medication has been reported as a risk factor for SCD among patients with coronary artery disease, but similar information concerning NIHD is scarce. Objectives: We evaluated the use of psychotropic medication in victims of SCD due to NIHD and compared it to the general medication use in Finland. Method: Study population was derived from the Finnish Genetic Study of Arrhythmic Events (Fingesture) ( n = 5,869, mean age: 65 ± 12, 79% males; 1,404 victims of SCD due to NIHD, mean age: 57 ± 13, 77% males). All deaths occurred in Northern Finland during 1998–2017. All victims underwent a medicolegal autopsy. Data on use of medication were defined using postmortem toxicology results and patient records. Subjects with neither toxicological analysis nor information of medication use available were excluded. Information on general medication use was derived from Finnish Statistics on Medicines 2018 and presented as defined daily dose/1,000 inhabitants/day. Results: Psychotropic medication was used by 579 (41%) subjects with NIHD, whereas in the general population, only 12% were estimated to use psychotropics. The results were similar in subgroups of psychotropic medication: 27% versus 2.3% for benzodiazepines, 19% versus 7.5% for antidepressants, and 18% versus 2.2% for antipsychotics. Conclusions: Use of psychotropic medication is common in victims of SCD due to NIHD compared to the general population.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          2023
          June 2023
          08 February 2023
          : 148
          : 2
          : 134-137
          Affiliations
          [_a] aResearch Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
          [_b] bForensic Medicine Unit, Finnish Institute for Health and Welfare, Oulu, Finland
          [_c] cDepartment of Forensic Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu, Oulu, Finland
          Author information
          https://orcid.org/0000-0002-3494-7652
          https://orcid.org/0000-0002-5692-243X
          https://orcid.org/0000-0003-1482-584X
          Article
          529501 Cardiology 2023;148:134–137
          10.1159/000529501
          36754034
          fb74783a-c099-4f0a-b6f4-40ce7b0f2559
          © 2023 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

          History
          : 08 December 2022
          : 26 January 2023
          Page count
          Figures: 1, Tables: 1, Pages: 4
          Funding
          This work was supported by the Ida Montin Foundation and Otto A. Malm Foundation.
          Categories
          Electrophysiology and Arrhythmia: Short Communication

          Medicine
          Sudden cardiac death,Medicolegal autopsy,Nonischemic heart disease,Psychotropic medication

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