<p class="first" id="d5769141e87">Paraquat (PRQ) is a toxic chemical compound that
is very noxious to animals and humans.
Gallic acid is a phenolic compound that has antioxidant properties. In this study,
we evaluated the ameliorative effect of gallic acid against PRQ-induced renal injury
and oxidative stress. In this research, the rats were segregated into six groups.
Group 1 is the control group; group 2 received paraquat only; group 3 received gallic
acid only; and groups 4, 5, and 6 received paraquat plus gallic acid at doses of 25,
50, and 100 mg/kg bw respectively. Findings of this work displayed that the renal
contents of the vitamin C, superoxide dismutase (SOD), and catalase (CAT) significantly
reduced and the levels of the serum protein carbonyl, creatinine, serum glutamate
pyruvate transaminase (sGPT), urea, serum glutamate oxaloacetate transaminase (sGOT),
uric acid, MDA, serum IL-1β, and the kidney IL-1β gene expression were remarkably
increased in the group receiving PRQ only compared with that in the control group.
On the other hand, treatment with gallic acid after exposure to PRQ led to a significant
elevation in renal vitamin C, SOD, and CAT levels plus a remarkable decrease in the
serum protein carbonyl, creatinine, sGPT, urea, sGOT, uric acid, MDA, IL-1β, and renal
gene expression of IL-1β in comparison with the PRQ-only-treated rats. Histological
changes were also ameliorated by gallic acid administration. The data approve that
gallic acid diminished the deleterious effects of PRQ exposure. In this regard, our
results indicated that the administration of gallic acid could alleviate the noxious
effects of PRQ on the antioxidant defense system and renal tissue.
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