Understanding the Binding Specificity of G-Protein Coupled Receptors toward G-Proteins and Arrestins: Application to the Dopamine Receptor Family

[1 ]CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal

[2 ]University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Faculty of Medicine, Pólo I, 1st floor, 3004-504 Coimbra, Portugal

[3 ]Institute for Interdisciplinary Research, University of Coimbra, Casa Costa Alemão - Pólo II | Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal

[4 ]Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, ao Km 139,7, 2695-066 Bobadela, Portugal

[5 ]European Bioinformatics Institute EMBL-EBI, Hinxton, Cambridgeshire CB10 1SD, United Kingdom

[6 ]GIGA Cyclotron Research Centre In Vivo Imaging, University of Liège, Bâtiment B30, Allée du 6 Août, 8, 4000 Liège, Belgium

[7 ]REQUIMTE/LAQV, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua Campo Alegre 687, s/n, 4169-007 Porto, Portugal

[8 ]Bijvoet Center for Biomolecular Research, Faculty of Science − Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

[9 ]Department of Life Sciences, University of Coimbra, Colégio de S. Bento, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal