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      Resistance mechanisms against quinolones in Mycoplasma capricolum subsp. capricolum.

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          Abstract

          Quinolones interact with bacterial DNA gyrase and topoisomerase IV, the subunits of which are encoded by gyrA/gyrB and parC/parE, respectively. The aim of this study was to evaluate the relationship between changes in these genes and quinolone susceptibility of Mycoplasma capricolum subsp. capricolum (Mcc). Using in vitro selected resistant mutants and field isolates from goats, predicted amino acid changes in gyrA, gyrB and parC were associated with higher minimum inhibitory concentration values for quinolones. Alterations in parC predicted amino acid sequences were most frequently associated with quinolone resistance in Mcc.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Vet J
          Title: Veterinary journal (London, England : 1997)
          Publisher: Elsevier BV
          ISSN (Electronic): 1532-2971
          ISSN (Print): 1090-0233
          Publication date (Electronic): May 2017
          Volume: 223
          Affiliations
          [1 ] Department of Animal Health, Faculty of Veterinary Sciences, Regional Campus of International Excellence 'Campus Mare Nostrum', Universidad de Murcia, Campus de Espinardo s/n, Murcia 30100, Spain.
          [2 ] Department of Animal Health, Faculty of Veterinary Sciences, Regional Campus of International Excellence 'Campus Mare Nostrum', Universidad de Murcia, Campus de Espinardo s/n, Murcia 30100, Spain. Electronic address: cdelafe@um.es.
          Article
          Publisher Item ID: S1090-0233(17)30074-6
          DOI: 10.1016/j.tvjl.2017.03.007
          PubMed ID: 28671064
          SO-VID: fba20b1a-22fd-42d1-ac3e-92e703c5df14
          Copyright © Copyright © 2017 Elsevier Ltd. All rights reserved.
          History

          Keywords: Antimicrobial resistance,Contagious agalactia,Mycoplasma capricolum subsp. capricolum,Quinolones
          Data availability:
          Keywords: Antimicrobial resistance, Contagious agalactia, Mycoplasma capricolum subsp. capricolum, Quinolones

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