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      The Ubiquitin Code

      1 , 2
      Annual Review of Biochemistry
      Annual Reviews

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          Abstract

          The posttranslational modification with ubiquitin, a process referred to as ubiquitylation, controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a single moiety or in the form of polymeric chains in which successive ubiquitin molecules are connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin modifications adopt distinct conformations and lead to different outcomes in cells. Here, we discuss the structure, assembly, and function of this ubiquitin code.

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          Author and article information

          Journal
          Annual Review of Biochemistry
          Annu. Rev. Biochem.
          Annual Reviews
          0066-4154
          1545-4509
          July 07 2012
          July 07 2012
          : 81
          : 1
          : 203-229
          Affiliations
          [1 ]Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom; email:
          [2 ]Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202; email:
          Article
          10.1146/annurev-biochem-060310-170328
          22524316
          fba34a7a-53c7-4c8b-869f-3e5138649545
          © 2012
          History

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