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      Vasodilating versus first-generation β-blockers for cardiovascular protection.

      1 , ,
      Postgraduate medicine
      Informa UK Limited

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          Abstract

          The utility of β-blockers in the treatment of hypertension has created much speculation as to their efficacy in patients with comorbid conditions, and there are concerns regarding their adverse metabolic effects. It is important to note that these findings were observed with traditional β-blockers, such as atenolol and metoprolol. The newer generation of β-blockers, namely carvedilol and nebivolol, is changing the manner in which β-blockers are viewed in hypertension management. Their ability to inhibit A1 adrenoreceptors and influence nitric oxide leads to vasodilation, which traditional β-blockers fail to do. These agents have been shown to have favorable metabolic effects while maintaining the beneficial cardiovascular effects of this drug class in post-myocardial infarction patients and the heart failure population.

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          Author and article information

          Journal
          Postgrad Med
          Postgraduate medicine
          Informa UK Limited
          1941-9260
          0032-5481
          Mar 2012
          : 124
          : 2
          Affiliations
          [1 ] Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA, USA.
          Article
          10.3810/pgm.2012.03.2532
          22437211
          fbae8f1e-9258-472f-a6fe-5c5785a6aba9
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