Acetate fuels the cancer engine.

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Abstract

Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.

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Journal

Journal ID (iso-abbrev): Cell

Title: Cell

ISSN (Electronic): 1097-4172

ISSN (Print): 0092-8674

Publication date (Electronic): Dec 18 2014

Volume: 159

Issue: 7

Affiliations

[1 ] Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address: col2007@med.cornell.edu.

[2 ] Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address: lcantley@med.cornell.edu.

Article

Publisher Item ID: S0092-8674(14)01579-7

DOI: 10.1016/j.cell.2014.12.009

PubMed ID: 25525870

SO-VID: fbb4acb3-dbd9-4dca-b932-33a165bfcf4d

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