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      Acetate fuels the cancer engine.

      1 , 2

      Cell

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          Abstract

          Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.

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          Author and article information

          Journal
          Cell
          Cell
          1097-4172
          0092-8674
          Dec 18 2014
          : 159
          : 7
          Affiliations
          [1 ] Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address: col2007@med.cornell.edu.
          [2 ] Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address: lcantley@med.cornell.edu.
          Article
          S0092-8674(14)01579-7
          10.1016/j.cell.2014.12.009
          25525870
          Copyright © 2014 Elsevier Inc. All rights reserved.

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