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      Functions of LIM-homeobox genes

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      Trends in Genetics
      Elsevier BV

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          Abstract

          Homeobox genes play fundamental roles in development. They can be subdivided into several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of LIM-homeobox genes has been remarkably conserved through evolution. Have their functions similarly been conserved? A host of new data has been derived from mutational analysis in diverse organisms, such as nematodes, flies and vertebrates. These studies have revealed a prominent involvement of LIM-homeodomain proteins in tissue patterning and differentiation, and their function in neural patterning is evident in all organisms studied to date. Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements.

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          Author and article information

          Journal
          Trends in Genetics
          Trends in Genetics
          Elsevier BV
          01689525
          February 2000
          February 2000
          : 16
          : 2
          : 75-83
          Article
          10.1016/S0168-9525(99)01883-1
          10652534
          fbc1c591-d7aa-4ba5-96f0-f8fab01c7384
          © 2000

          https://www.elsevier.com/tdm/userlicense/1.0/

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