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      Antioxidants of Edible Mushrooms

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          Abstract

          Oxidative stress caused by an imbalanced metabolism and an excess of reactive oxygen species (ROS) lead to a range of health disorders in humans. Our endogenous antioxidant defense mechanisms and our dietary intake of antioxidants potentially regulate our oxidative homeostasis. Numerous synthetic antioxidants can effectively improve defense mechanisms, but because of their adverse toxic effects under certain conditions, preference is given to natural compounds. Consequently, the requirements for natural, alternative sources of antioxidant foods identified in edible mushrooms, as well as the mechanistic action involved in their antioxidant properties, have increased rapidly. Chemical composition and antioxidant potential of mushrooms have been intensively studied. Edible mushrooms might be used directly in enhancement of antioxidant defenses through dietary supplementation to reduce the level of oxidative stress. Wild or cultivated, they have been related to significant antioxidant properties due to their bioactive compounds, such as polyphenols, polysaccharides, vitamins, carotenoids and minerals. Antioxidant and health benefits, observed in edible mushrooms, seem an additional reason for their traditional use as a popular delicacy food. This review discusses the consumption of edible mushrooms as a powerful instrument in maintaining health, longevity and life quality.

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          Most cited references217

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          Aging: a theory based on free radical and radiation chemistry.

          D. Harman (1956)
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            Antioxidants prevent health-promoting effects of physical exercise in humans.

            Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unknown. We evaluated the effects of a combination of vitamin C (1000 mg/day) and vitamin E (400 IU/day) on insulin sensitivity as measured by glucose infusion rates (GIR) during a hyperinsulinemic, euglycemic clamp in previously untrained (n = 19) and pretrained (n = 20) healthy young men. Before and after a 4 week intervention of physical exercise, GIR was determined, and muscle biopsies for gene expression analyses as well as plasma samples were obtained to compare changes over baseline and potential influences of vitamins on exercise effects. Exercise increased parameters of insulin sensitivity (GIR and plasma adiponectin) only in the absence of antioxidants in both previously untrained (P < 0.001) and pretrained (P < 0.001) individuals. This was paralleled by increased expression of ROS-sensitive transcriptional regulators of insulin sensitivity and ROS defense capacity, peroxisome-proliferator-activated receptor gamma (PPARgamma), and PPARgamma coactivators PGC1alpha and PGC1beta only in the absence of antioxidants (P < 0.001 for all). Molecular mediators of endogenous ROS defense (superoxide dismutases 1 and 2; glutathione peroxidase) were also induced by exercise, and this effect too was blocked by antioxidant supplementation. Consistent with the concept of mitohormesis, exercise-induced oxidative stress ameliorates insulin resistance and causes an adaptive response promoting endogenous antioxidant defense capacity. Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.
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              Natural Antioxidants: Sources, Compounds, Mechanisms of Action, and Potential Applications

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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Molecules
                Molecules
                molecules
                Molecules
                MDPI
                1420-3049
                27 October 2015
                October 2015
                : 20
                : 10
                : 19489-19525
                Affiliations
                [1 ]Department for Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, Nemanjina 6, Belgrade 11080, Serbia; E-Mail: maja@ 123456agrif.bg.ac.rs
                [2 ]Department for Industrial Microbiology, Faculty of Agriculture, University of Belgrade, Nemanjina 6, Belgrade 11080, Serbia; E-Mails: aklaus@ 123456agrif.bg.ac.rs (A.K.); vampum00@ 123456yahoo.com (J.V.); mniksic@ 123456agrif.bg.ac.rs (M.N.)
                [3 ]Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoseva 12, Belgrade 11001, Serbia; E-Mails: djakovlj@ 123456chem.bg.ac.rs (D.J.); ninat@ 123456chem.bg.ac.rs (N.T.); mmvchem@ 123456sezampro.rs (M.M.V.)
                [4 ]Institute of Chemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade 11060, Serbia; E-Mail: ppetrovic@ 123456tmf.bg.ac.rs
                [5 ]Faculty of Chemistry, University of Belgrade, Studentski trg 12–16, Belgrade 11000, Serbia
                [6 ]Plant Research International, Wageningen University and Research Centre, Droevendaalsesteeg 1, Wageningen 6700 AA, The Netherlands
                Author notes
                [* ] Author to whom correspondence should be addressed; E-Mail: leo.vangriensven@ 123456wur.nl or leo.vangriensven@ 123456gmail.com ; Tel.: +31-748-0992; Fax: +31-741-8094.
                Article
                molecules-20-19489
                10.3390/molecules201019489
                6331815
                26516828
                fbd603a1-bd42-4253-b5dc-6e7eb0b4e668
                © 2015 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 04 September 2015
                : 21 October 2015
                Categories
                Review

                antioxidants,edible mushrooms,health,life quality,longevity,oxidative stress,reactive oxygen species

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