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      COVID-19 mortality as a fingerprint of biological age

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          Abstract

          Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19. There is a need for systematic, consequent action of identifying frail (not only older, not only multimorbid, not only symptomatic) persons at risk of poor outcomes in order to protect our oldest generation from COVID-19.

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          Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

          Giacomo Grasselli, Alberto Zangrillo, Alberto Zanella … (2020)
          In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.
          Article 0 comments Cited 2760 times – based on 0 reviews     Review now
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            Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

            Graziano Onder, Giovanni Rezza, Silvio Brusaferro (2020)
            Article 0 comments Cited 2021 times – based on 0 reviews     Review now
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              Is Open Access

              Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period

              Stephen M. Kissler, Christine Tedijanto, Edward Goldstein … (2020)
              It is urgent to understand the future of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) transmission. We used estimates of seasonality, immunity, and cross-immunity for betacoronaviruses OC43 and HKU1 from time series data from the USA to inform a model of SARS-CoV-2 transmission. We projected that recurrent wintertime outbreaks of SARS-CoV-2 will probably occur after the initial, most severe pandemic wave. Absent other interventions, a key metric for the success of social distancing is whether critical care capacities are exceeded. To avoid this, prolonged or intermittent social distancing may be necessary into 2022. Additional interventions, including expanded critical care capacity and an effective therapeutic, would improve the success of intermittent distancing and hasten the acquisition of herd immunity. Longitudinal serological studies are urgently needed to determine the extent and duration of immunity to SARS-CoV-2. Even in the event of apparent elimination, SARS-CoV-2 surveillance should be maintained since a resurgence in contagion could be possible as late as 2024.
              Article 0 comments Cited 1199 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Ageing Res Rev
                Journal ID (iso-abbrev): Ageing Res Rev
                Title: Ageing Research Reviews
                Publisher: Published by Elsevier B.V.
                ISSN (Print): 1568-1637
                ISSN (Electronic): 1872-9649
                Publication date PMC-release: 20 February 2021
                Publication date (Electronic): 20 February 2021
                Electronic Location Identifier: 101308
                Affiliations
                [a ]Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
                [b ]Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
                [c ]Institute of Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
                [d ]Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
                [e ]National Institute on Aging, Baltimore, MD, USA
                Author notes
                [* ]Corresponding author at: Ageing Clinical Research, Department II of Internal Medicine and Center of Molecular Medicine Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
                Article
                Publisher Item ID: S1568-1637(21)00055-6 Publisher ID: 101308
                DOI: 10.1016/j.arr.2021.101308
                PMC ID: 7896489
                PubMed ID: 33621704
                SO-VID: fbeeba77-e55b-4dd7-b0a6-618abe4e2ac7
                Copyright © © 2021 Published by Elsevier B.V.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Date received : 7 May 2020
                Date revision received : 9 February 2021
                Date accepted : 18 February 2021
                Categories
                Subject: Review

                Keywords: biological age,corona virus disease 2019,covid-19,frailty,severe acute respiratory syndrome-corona virus 2,sars-cov-2
                Data availability:
                Keywords: biological age, corona virus disease 2019, covid-19, frailty, severe acute respiratory syndrome-corona virus 2, sars-cov-2

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