MALDI-MSI Pilot Study Highlights Glomerular Deposits of Macrophage Migration Inhibitory Factor as a Possible Indicator of Response to Therapy in Membranous Nephropathy.

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Abstract

Membranous nephropathy (MN) is the most frequent cause of nephrotic syndrome in adults and the disease course is characterized by the "rule of third", with one-third of patients experiencing complete remission and the remaining experiencing relapses or progression of the disease. Additionally, the therapeutic approach is not standardized, leading to further heterogeneity in terms of response and outcome.

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Journal ID (iso-abbrev): Proteomics Clin Appl

Title: Proteomics. Clinical applications

Publisher: Wiley

ISSN (Electronic): 1862-8354

ISSN (Print): 1862-8346

Publication date (Electronic): May 2019

Volume: 13

Issue: 3

Affiliations

[1 ] Department of Medicine and Surgery, Pathology, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy.

[2 ] Department of Medicine and Surgery, Clinical Proteomics and Metabolomics Unit, University of Milano-Bicocca, Vedano al Lambro, Italy.

[3 ] Department of Medicine and Surgery, Nephrology Unit, University of Milano-Bicocca, Monza, Italy.

[4 ] Department of Nephrology, Santa Marta e Santa Venera Hospital, Acireale, Italy.

[5 ] Department of Nephrology, Ospedale Agostino Gemelli, Rome, Italy.

[6 ] Research Center for Renal Immunopathology, University of Milan, Milan, Italy.

[7 ] Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy.

Article

DOI: 10.1002/prca.201800019

PubMed ID: 30358918

SO-VID: fc157c17-71c6-4c6c-b767-3f54d77e2cbf

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Keywords: macrophage migration inhibitory factor,membranous nephropathy,proteomics,mass spectrometry,MALDI-MSI

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Keywords: macrophage migration inhibitory factor, membranous nephropathy, proteomics, mass spectrometry, MALDI-MSI

MALDI-MSI Pilot Study Highlights Glomerular Deposits of Macrophage Migration Inhibitory Factor as a Possible Indicator of Response to Therapy in Membranous Nephropathy.

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