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      Contributions of meta-analyses based on individual patient data to therapeutic progress in colorectal cancer.

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      International journal of clinical oncology
      Springer Nature America, Inc

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          Abstract

          Meta-analysis is the statistical process of combining information from several studies addressing the same question. Meta-analyses based on individual patient data are far more reliable and informative than those based on summary statistics obtained from the trialists or extracted from the published literature. Meta-analysis of randomized clinical trials may contribute to therapeutic progress through (1) establishing efficacy benefits beyond a reasonable doubt, (2) identifying sources of heterogeneity between trials, (3) studying subsets reliably, (4) confirming differences in toxicity profiles, (5) evaluating the cost-effectiveness of experimental therapies, (6) assessing surrogate endpoints, and (7) addressing ancillary questions. All of these potential contributions are illustrated with examples in early and advanced colorectal cancer.

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          Author and article information

          Journal
          Int. J. Clin. Oncol.
          International journal of clinical oncology
          Springer Nature America, Inc
          1341-9625
          1341-9625
          Apr 2009
          : 14
          : 2
          Affiliations
          [1 ] International Drug Development Institute, Louvain-la-Neuve, Belgium. marc.buyse@iddi.com
          Article
          10.1007/s10147-009-0879-2
          19390939
          fc223c18-104e-4c6f-afd2-cb652db54ccb
          History

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