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      Validity of Height Velocity as a Diagnostic Criterion for Idiopathic Growth Hormone Deficiency and Turner Syndrome

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          A deflecting growth curve over several years is sometimes the only indication for the possible presence of a growth disorder. In this study we looked at the potential diagnostic role of long-term downward deflection of the growth curve. It reports on the diagnostic validity of height velocity over 1, 2 or 3 years for isolated idiopathic growth hormone deficiency and for Turner syndrome in prepubertal children with a height that is still above –2.5 standard deviation scores (SDS). 1-year height velocity was found to have no diagnostic value because of an almost complete overlap of height velocity distributions with normal prepubertal children. However, height velocity over 3 years was found to have an acceptable validity in children 5–12 years old. In this age range a change in height SDS of –0.75 can be used as a valid criterion for further examination of karyotype and GH secretion capacity even if there are no other clear signs of a particular growth disorder.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          February 1999
          02 June 1999
          : 51
          : 2
          : 68-73
          aDutch Growth Foundation, Rotterdam, and bLeiden University Medical Center, Leiden, The Netherlands
          23317 Horm Res 1999;51:68–73
          © 1999 S. Karger AG, Basel

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          Page count
          Figures: 3, Tables: 2, References: 8, Pages: 6
          Original Paper


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