Validity of Height Velocity as a Diagnostic Criterion for Idiopathic Growth Hormone Deficiency and Turner Syndrome

Abstract

A deflecting growth curve over several years is sometimes the only indication for the possible presence of a growth disorder. In this study we looked at the potential diagnostic role of long-term downward deflection of the growth curve. It reports on the diagnostic validity of height velocity over 1, 2 or 3 years for isolated idiopathic growth hormone deficiency and for Turner syndrome in prepubertal children with a height that is still above –2.5 standard deviation scores (SDS). 1-year height velocity was found to have no diagnostic value because of an almost complete overlap of height velocity distributions with normal prepubertal children. However, height velocity over 3 years was found to have an acceptable validity in children 5–12 years old. In this age range a change in height SDS of –0.75 can be used as a valid criterion for further examination of karyotype and GH secretion capacity even if there are no other clear signs of a particular growth disorder.