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Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression.
Philipp Hegner
1 ,
Simon Lebek
1 ,
Maria Tafelmeier
1 ,
Daniele Camboni
2 ,
Simon Schopka
2 ,
Christof Schmid
2 ,
Lars Siegfried Maier
1 ,
Michael Arzt
1 ,
Stefan Wagner
3
December 2021
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Abstract
Patients with atrial fibrillation (AF) exhibit decreased atrial expression of connexin (Cx), which has been causally linked to a proarrhythmogenic substrate. Interestingly, patients with sleep-disordered breathing (SDB) are at increased risk of AF, but the mechanisms remain unclear.