Using an in vitro model to study oxidised protein accumulation in ageing fibroblasts.

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Abstract

The accumulation of oxidised proteins in ageing cells and tissues results from an increase in oxidant damage coupled with impaired degradation of the damaged proteins. Heat Shock Proteins (HSP) and other chaperones are required to recognise damaged proteins and transport them to the lysosomal and proteasomal degradation pathways. How these systems fail in ageing cells is not clear.

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Journal

Journal ID (iso-abbrev): Biochim. Biophys. Acta

Title: Biochimica et biophysica acta

Publisher: Elsevier BV

ISSN: 0006-3002

ISSN (Print): 0006-3002

Publication date (Electronic): Nov 2015

Volume: 1850

Issue: 11

Affiliations

[1 ] The Cell Biology Group, School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.

[2 ] The Cell Biology Group, School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address: Kenneth.rodgers@uts.edu.au.

Article

Publisher Item ID: S0304-4165(15)00178-6

DOI: 10.1016/j.bbagen.2015.07.002

PubMed ID: 26187876

SO-VID: fc48b224-1193-4f58-9646-10b523cc5f20

History

Keywords: Proteasome,Oxidised proteins,Lysosomes,DOPA,Ageing

Data availability:

Keywords: Proteasome, Oxidised proteins, Lysosomes, DOPA, Ageing

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