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      Orphan Status may be Protective Factor Against Severe

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          Abstract

          Background: Orphan status is usually a risk factor for many diseases and results in social exclusion and worse outcomes than children with parents. Methods: The case reports of severe toxicity where death was averted by close monitoring in an orphanage in Phnom Penh, Cambodia are presented. Results: Close monitoring of adherence of antiretroviral therapy (ARV) is possible only in close facility, e.g. orphanage, where regular DOT (directly observed therapy) and DOTOX (directly observed toxicity) is possible. Conclusions: Three cases of severe toxicity: two bone marrow severe suppression and one cardiomyopathy are presented. Deaths were averted by close observation and early interventions.

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          Adherence to antiretroviral therapy in children: a study of prevalence and associated factors

          The survival of children with AIDS has increased considerably with the use of more effective antiretrovirals, but the benefits of this therapy are limited by the difficulty of adherence to the treatment. This cross-sectional study aimed to estimate the prevalence of non-adherence to antiretrovirals among children residents in Porto Alegre, Rio Grande do Sul State, Brazil, and identifying associated factors. There were 194 child caregivers interviewed. The technique utilized to evaluate adherence allowed the detection of lack of understanding of the prescribed antiretroviral regimens, as well as conscious loss of doses. Non-adherence was defined when the child had taken less than 80% of the prescribed medication during the 24h period prior to the interview. A general prevalence of non-adherence was 49.5%, which was higher than that estimated. The non-institutional caregivers had a prevalence rate of 55.7%, while the institutional caregivers had 22.2%. In multivariate analysis, the education of the caregiver was found to have a borderline association with the outcome. Institutionalized children and those taken care of by people with a higher educational level appeared to have more protection against non-adherence to antiretroviral therapy.
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            Author and article information

            Journal
            Clinical Social Work and Health Intervention
            CSWHI
            Journal of Clinical Social Work and Health Intervention
            2222386X
            20769741
            October 31 2018
            October 27 2018
            October 31 2018
            October 27 2018
            : 9
            : 3
            : 71-73
            Article
            10.22359/cswhi_9_3_10
            © 2018

            This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

            Psychology, Social & Behavioral Sciences

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