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      PB.30. Apparent diffusion coefficient and fractional anisotropy values as biomarkers for treatment response in breast cancer

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      Breast Cancer Research : BCR

      BioMed Central

      British Society of Breast Radiology Annual Scientific Meeting 2014

      10-11 November 2014

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          Introduction The aim was to evaluate whether changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values predict early response in patients receiving neoadjuvant chemotherapy (NACT) for breast cancer and to assess the effect of tumour marker clip placement on ADC values. Methods Twenty patients with invasive breast carcinoma underwent MRI at three time points: at baseline (TP0) and following the first (TP1) and second (TP2) cycles of NACT. 3T MRI (Achieva; Philips) was performed using a standard protocol including diffusion-weighted and diffusion tensor imaging. Baseline and sequential data in responder and nonresponder groups were compared. To assess the effects of a commercially available titanium-hydrogel clip on ADC values, DWI was performed on a phantom consisting of a clip embedded in a tumour-mimicking target. Results At baseline, mean tumour ADC (0.92 × 10-3 mm2/second) was statistically lower than disease-free fibroglandular breast tissue (1.75 × 10-3 mm2/second) (P < 0.0001). Mean FA values of tumour (FA = 0.139) and disease-free tissue (FA = 0.135) were similar. Compared with baseline values, tumour ADC of responders significantly increased at TP1 (P < 0.0001) and TP2 (P < 0.0001) while a significant increase in tumour FA of responders was seen at TP2 (P < 0.008). No statistical change occurred in tumour ADC or FA values of the nonresponder group. The ADC value of the clip in the phantom (1.7 × 10-3 mm2/second) was higher than the ADC value of surrounding tumour (1.4 × 10-3 mm2/second). Conclusion Changes in ADC and FA values early in the course of treatment may predict response in patients receiving NACT for breast cancer. The gel-containing clip used for tumour marking prior to NACT results in a source of error when calculating tumour ADC values and should be avoided when drawing regions of interest.

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          Author and article information

          Breast Cancer Res
          Breast Cancer Res
          Breast Cancer Research : BCR
          BioMed Central
          3 November 2014
          : 16
          : Suppl 1
          : P39
          [1 ]Centre for Advanced Medical Imaging, St James's Hospital, Dublin, Ireland
          Copyright © 2014 Joyce et al.; licensee BioMed Central Ltd.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

          British Society of Breast Radiology Annual Scientific Meeting 2014
          Brighton, UK
          10-11 November 2014
          Poster Presentation

          Oncology & Radiotherapy


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