There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
The aim was to evaluate whether changes in apparent diffusion coefficient (ADC) and
fractional anisotropy (FA) values predict early response in patients receiving neoadjuvant
chemotherapy (NACT) for breast cancer and to assess the effect of tumour marker clip
placement on ADC values.
Twenty patients with invasive breast carcinoma underwent MRI at three time points:
at baseline (TP0) and following the first (TP1) and second (TP2) cycles of NACT. 3T
MRI (Achieva; Philips) was performed using a standard protocol including diffusion-weighted
and diffusion tensor imaging. Baseline and sequential data in responder and nonresponder
groups were compared. To assess the effects of a commercially available titanium-hydrogel
clip on ADC values, DWI was performed on a phantom consisting of a clip embedded in
a tumour-mimicking target.
At baseline, mean tumour ADC (0.92 × 10-3 mm2/second) was statistically lower than
disease-free fibroglandular breast tissue (1.75 × 10-3 mm2/second) (P < 0.0001). Mean
FA values of tumour (FA = 0.139) and disease-free tissue (FA = 0.135) were similar.
Compared with baseline values, tumour ADC of responders significantly increased at
TP1 (P < 0.0001) and TP2 (P < 0.0001) while a significant increase in tumour FA of
responders was seen at TP2 (P < 0.008). No statistical change occurred in tumour ADC
or FA values of the nonresponder group. The ADC value of the clip in the phantom (1.7
× 10-3 mm2/second) was higher than the ADC value of surrounding tumour (1.4 × 10-3
Changes in ADC and FA values early in the course of treatment may predict response
in patients receiving NACT for breast cancer. The gel-containing clip used for tumour
marking prior to NACT results in a source of error when calculating tumour ADC values
and should be avoided when drawing regions of interest.
This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (
http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided
the original work is properly cited. The Creative Commons Public Domain Dedication
http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
British Society of Breast Radiology Annual Scientific Meeting 2014