Does a Carbon Ion-Implanted Surface Reduce the Restenosis Rate of Coronary Stents?

Abstract

Background: Neointimal hyperplasia and resulting restenosis limit the long-term success of coronary stenting. Heavy metal ions induce an inflammatory and allergic reaction, and result in in-stent restenosis. However, a carbon ion-implanted surface might prevent heavy metal ions from diffusing into surrounding tissue. Methods: 140 lesions in 140 patients with coronary lesions underwent implantation of carbon-implanted surface stents (Arthos^inert stent group, n = 70) or control stents (Arthos stent group, n = 70). The primary end point was the in-stent restenosis and the secondary end point was the value of hs-CRP at 48 h and 6 months after coronary stenting. Clinical and angiographic follow-ups were performed at 6 months. Results: The rate of in-stent restenosis was lower in the Arthos^inert stent group (15.9%, 10/63) than in the Arthos stent group (20.9%, 13/62), but there were no significant differences between both groups (p = 0.56). The value of hs-CRP at 48 h was lower in the Arthos^inert stent group (13.9 ± 13.4 mg/dl) than in the Arthos stent group (24.5 ± 26.0 mg/dl) with significant differences (p = 0.04). However, the differences between two groups were not statistically significant at 6 months (p = 0.76). Conclusions: As compared with a standard coronary stent, a carbon ion-implanted stent shows no considerable benefit for the prevention of in-stent restenosis within the range of this study. Despite all the limitations of this study, a positive effect of a carbon ion-implanted stent in reducing inflammatory reaction after coronary revascularization seems likely.

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 2005

Publication date (Print): August 2005

Publication date (Electronic): 24 August 2005

Volume: 104

Issue: 2

Pages: 72-75

Affiliations

^aCardiovascular Division, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University Medical Center and ^bCardiovascular Division of Yonsei Cardiovascular Center and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea

Article

Publisher ID: 86688 Other ID: Cardiology 2005;104:72–75

DOI: 10.1159/000086688

PubMed ID: 16020923

Copyright statement: © 2005 S. Karger AG, Basel

License:

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Page count

Tables: 3, References: 20, Pages: 4

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Categories

Subject: Cardiac Catheterization and Interventional Cardiology