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      Identification of Suitable Biomarkers for Stress and Emotion Detection for Future Personal Affective Wearable Sensors

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          Abstract

          Skin conductivity (i.e., sweat) forms the basis of many physiology-based emotion and stress detection systems. However, such systems typically do not detect the biomarkers present in sweat, and thus do not take advantage of the biological information in the sweat. Likewise, such systems do not detect the volatile organic components (VOC’s) created under stressful conditions. This work presents a review into the current status of human emotional stress biomarkers and proposes the major potential biomarkers for future wearable sensors in affective systems. Emotional stress has been classified as a major contributor in several social problems, related to crime, health, the economy, and indeed quality of life. While blood cortisol tests, electroencephalography and physiological parameter methods are the gold standards for measuring stress; however, they are typically invasive or inconvenient and not suitable for wearable real-time stress monitoring. Alternatively, cortisol in biofluids and VOCs emitted from the skin appear to be practical and useful markers for sensors to detect emotional stress events. This work has identified antistress hormones and cortisol metabolites as the primary stress biomarkers that can be used in future sensors for wearable affective systems.

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          Most cited references58

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          Aptamers: an emerging class of molecules that rival antibodies in diagnostics.

          Antibodies, the most popular class of molecules providing molecular recognition needs for a wide range of applications, have been around for more than three decades. As a result, antibodies have made substantial contributions toward the advancement of diagnostic assays and have become indispensable in most diagnostic tests that are used routinely in clinics today. The development of the systematic evolution of ligands by exponential enrichment (SELEX) process, however, made possible the isolation of oligonucleotide sequences with the capacity to recognize virtually any class of target molecules with high affinity and specificity. These oligonucleotide sequences, referred to as "aptamers", are beginning to emerge as a class of molecules that rival antibodies in both therapeutic and diagnostic applications. Aptamers are different from antibodies, yet they mimic properties of antibodies in a variety of diagnostic formats. The demand for diagnostic assays to assist in the management of existing and emerging diseases is increasing, and aptamers could potentially fulfill molecular recognition needs in those assays. Compared with the bellwether antibody technology, aptamer research is still in its infancy, but it is progressing at a fast pace. The potential of aptamers may be realized in the near future in the form of aptamer-based diagnostic products in the market. In such products, aptamers may play a key role either in conjunction with, or in place of, antibodies. It is also likely that existing diagnostic formats may change according to the need to better harness the unique properties of aptamers.
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            Aptamers and Their Biological Applications

            Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocellulose membrane filtration, affinity chromatography, magnetic bead, and capillary electrophoresis-based selection methods, are explained in detail. We also introduce various applications of aptamers for the diagnosis of diseases and detection of small molecules. Numerous analytical techniques, such as electrochemical, colorimetric, optical, and mass-sensitive methods, can be utilized to detect targets, due to convenient modifications and the stability of aptamers. Finally, several medical and analytical applications of aptamers are presented. In summary, aptamers are promising materials for diverse areas, not just as alternatives to antibodies, but as the core components of medical and analytical equipment.
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              • Record: found
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              Molecularly selective nanoporous membrane-based wearable organic electrochemical device for noninvasive cortisol sensing

              A new wearable nanoporous organic electrochemical device used as a medical diagnostics tool for noninvasive hormone sensing.
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                Author and article information

                Journal
                Biosensors (Basel)
                Biosensors (Basel)
                biosensors
                Biosensors
                MDPI
                2079-6374
                16 April 2020
                April 2020
                : 10
                : 4
                : 40
                Affiliations
                [1 ]Biomedical Sciences and Biomedical Engineering, The University of Reading, Reading RG6 6AY, UK; a.a.a.zamkah@ 123456pgr.reading.ac.uk (A.Z.); t.k.hui@ 123456reading.ac.uk (T.H.); s.c.andrews@ 123456reading.ac.uk (S.A.)
                [2 ]Department of Information Technology, Techno India College of Technology, West Bengal 700156, India; neelanjan.dey@ 123456gmail.com
                [3 ]Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 08903, USA; fuqian.shi@ 123456rutgers.edu
                Author notes
                [* ]Correspondence: r.s.sherratt@ 123456reading.ac.uk ; Tel.: +44-118-378-8588
                Author information
                https://orcid.org/0000-0001-7245-1183
                https://orcid.org/0000-0002-7513-1887
                https://orcid.org/0000-0003-4295-2686
                https://orcid.org/0000-0001-8437-498X
                https://orcid.org/0000-0001-7899-4445
                Article
                biosensors-10-00040
                10.3390/bios10040040
                7235866
                32316280
                fc6669b9-f836-42cf-b71f-9d2bf4ee15c5
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 30 January 2020
                : 13 April 2020
                Categories
                Review

                stress,emotion,cortisol,volatile organic components,biomarkers,wearable sensors

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